Table 9 Significance Levels by Substance

Atrial septal defect

2.2e-320

0.0215

9.26E-39

0.00536446

1.09E-08

2.2e-320

Ventricular septal defect

7.36E-08

0.1490

1.24E-20

1.93E-04

0.0033

2.2e-320

Hypospadias

2.2e-320

0.4362

0.0317

0.7536

1.38E-05

1.02E-289

Tricuspid valve atresia and stenosis

7.29E-10

0.1377

4.01E-159

6.31E-04

3.93E-04

1.36E-50

Renal agenesis/hypoplasia

5.30E-11

0.0215

0.0606

2.82E-09

0.0028

1.63E-50

Obstructive genitourinary defect

0.0012

0.4876

4.12E-05

2.37E-09

3.92E-12

2.22E-15

Pulmonary valve atresia and stenosis

0.9716

0.0408

0.4950

3.64E-08

1.27E-08

9.14E-12

Anophthalmia/microphthalmia

8.86E-04

0.6781

7.92E-05

3.62E-04

1.48E-12

2.12E-08

Craniosynostosis

1.80E-05

1.0000

0.0266

0.7020

7.18E-05

2.31E-08

Holoprosencephaly

1.66E-28

2.00E-15

5.89E-08

2.02E-04

2.90E-12

2.34E-08

Reduction deformity, Upper limbs

0.1301

0.4407

0.7110

0.0042

1.15E-09

2.01E-06

Cleft palate alone

2.29E-11

0.6532

3.78E-07

0.2282

0.0892

3.47E-06

Small intestinal atresia/stenosis

0.0106

0.0125

0.0775

0.0531

4.47E-06

5.93E-06

Pulmonary valve atresia

0.4522

0.0978

2.23E-17

0.6602

2.62E-05

1.02E-05

Omphalocele

8.62E-04

6.56E-06

0.0288

7.27E-07

0.0056

2.49E-05

Cloacal exstrophy

1.36E-45

0.0284

1.91E-12

6.90E-11

2.13E-86

5.45E-04

Turner syndrome

9.14E-11

0.0367

0.7522

0.0014

7.69E-49

5.63E-04

Common truncus (truncus arteriosus)

7.03E-22

1.02E-08

0.8321

7.90E-05

2.51E-05

6.55E-04

Microcephalus

3.39E-07

7.86E-06

0.1067

0.1136

1.90E-13

7.11E-04

Choanal atresia

1.42E-07

0.7186

0.0014

0.0290

2.26E-05

7.34E-04

Limb deficiencies (reduction defects)

0.0428

0.0034

0.0405

1.72E-06

2.33E-06

8.14E-04

Trisomy 21 (Down syndrome)

1.75E-07

0.0895

0.1491

1.49E-55

4.02E-26

0.0021

Clubfoot

0.4663

3.66E-06

0.2788

0.7378

0.0136

0.0048

Epispadias

0.0915

0.1591

0.0084

0.0242

0.0287

0.0081

Cleft lip with and without cleft palate

0.1248

0.1441

3.43E-11

0.5715

0.0887

0.0159

Ebstein anomaly

0.1232

1.57E-04

3.81E-05

0.2279

0.0643

0.0177

Biliary atresia

0.7657

4.48E-06

0.1548

0.2026

0.0244

0.0233

Diaphragmatic hernia

5.26E-07

5.72E-05

0.0011

0.0013

2.11E-08

0.0373

Double outlet right ventricle

0.5739

4.13E-08

0.0314

0.0743

7.31E-04

0.0379

Congenital cataract

0.2114

0.1134

0.1381

0.5892

0.2537

0.0416

Trisomy 13

1.77E-11

0.5945

4.20E-09

3.06E-106

3.50E-06

0.0427

Single ventricle

0.1289

2.42E-10

0.3626

0.0037

0.0060

0.0482

Pyloric stenosis

1.38E-84

0.1051

1.78E-122

9.40E-29

4.82E-04

0.0657

Total anomalous pulmonary venous connection

1.05E-07

1.64E-06

9.84E-07

3.78E-04

0.4381

0.0773

Atrioventricular septal defect

0.0937

6.48E-12

0.0269

0.0073

0.0470

0.0854

Hydrocephalus without spina bifida

1.84E-09

0.4705

0.0011

0.5085

0.2200

0.1441

Dextro-transposition of great arteries (d-TGA)

8.25E-04

0.0513

0.4822

0.0198

1.40E-10

0.1529

Deletion 22q11.2

6.98E-05

0.0672

3.67E-28

4.72E-08

0.0051

0.2047

Congenital hip dislocation

0.1991

0.1493

0.3536

1.13E-27

7.27E-70

0.2063

Reduction deformity, Lower limbs

0.0231

0.5017

0.6312

0.0277

0.0253

0.2401

Tetralogy of Fallot

0.0047

7.04E-11

0.2681

0.6597

0.1692

0.2530

Hirschsprung disease (congenital megacolon)

0.1818

1.55E-08

0.4987

0.9565

6.69E-06

0.3010

Trisomy 18

6.05E-04

0.0140

0.0034

2.43E-08

1.06E-61

0.3486

Bladder exstrophy

0.0011

0.5975

0.3200

0.3343

0.8681

0.3893

Patent ductus arteriosus

0.0375

0.8028

2.36E-07

1.22E-09

5.95E-39

0.4386

Esophageal atresia/tracheoesophageal fistula

0.0977

0.2148

0.3880

0.8914

0.0195

0.4602

Hypoplastic left heart syndrome

1.91E-05

1.35E-14

0.0014

0.0080

0.0048

0.5102

Anencephalus

0.0269

1.45E-10

4.05E-44

0.1442

7.15E-05

0.5233

Coarctation of the aorta

5.48E-07

0.8820

3.82E-08

1.56E-07

9.74E-45

0.5283

Amniotic Bands

0.7468

0.0026

0.0271

0.0681

0.3785

0.5349

Encephalocele

0.0079

4.74E-06

0.1125

0.0397

0.1289

0.5605

Congenital posterior urethral valves

0.2039

8.57E-11

0.4012

0.0184

1.35E-04

0.5725

Interrupted aortic arch

0.0582

0.2411

0.0022

0.0472

0.7274

0.5788

Cleft lip alone

0.2215

0.4773

1.95E-04

1.40E-06

0.4216

0.5998

Aortic valve stenosis

0.4160

6.46E-09

9.78E-36

0.4210

0.0011

0.6318

Transposition of great arteries

1.49E-08

5.27E-07

4.54E-08

1.54E-05

0.7669

0.7385

Cleft lip with cleft palate

1.92E-04

2.58E-04

3.32E-04

0.0304

0.1508

0.7455

Anotia/microtia

9.45E-10

0.0148

4.05E-37

2.02E-64

0.9670

0.8853

Gastroschisis

0.9978

0.0014

9.74E-13

0.3662

0.0098

0.8919

Rectal and large intestinal atresia/stenosis

4.34E-08

2.94E-06

0.0493

1.69E-04

0.0011

0.8966

Spina bifida without anencephalus

0.2806

5.86E-06

2.14E-29

0.9854

0.0181

0.9332

Aniridia

0.5068

0.0073

6.17E-04

0.0096

0.0952

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