Congenital Anomaly | Cigarettes Prevalence Ratio | Binge Alcohol Prevalence Ratio | Analgesics Prevalence Ratio | Ccoaine Prevalence Ratio | Cannabis Prevalence Ratio | Cannabidiol Prevalence Ratio |
---|---|---|---|---|---|---|
Obstructive genitourinary defect | 0.92 (0.87, 0.97) | 1.02 (0.97, 1.07) | 0.9 (0.85, 0.94) | 1.17 (1.11, 1.23) | 0.86 (0.82, 0.9) | 1.92 (1.63, 2.27) |
Cleft lip with and without cleft palate | 1.06 (0.98, 1.13) | 0.95 (0.88, 1.02) | 1.3 (1.2, 1.41) | 1.02 (0.94, 1.11) | 0.94 (0.87, 1.01) | 1.52 (1.08, 2.14) |
Pulmonary valve atresia | 1.06 (0.91, 1.22) | 0.45 (0.38, 0.54) | 1.64 (1.46, 1.85) | 0.97 (0.86, 1.1) | 1.27 (1.14, 1.43) | 1.35 (1.18, 1.55) |
Cloacal exstrophy | 2.84 (2.44, 3.31) | 0.85 (0.73, 0.98) | 1.61 (1.41, 1.83) | 0.63 (0.54, 0.72) | 4.85 (4.08, 5.77) | 1.3 (1.12, 1.51) |
Hirschsprung disease (congenital megacolon) | 1.12 (0.95, 1.33) | 0.57 (0.47, 0.7) | 1.06 (0.89, 1.27) | 1.01 (0.84, 1.21) | 1.46 (1.24, 1.72) | 1.29 (0.8, 2.09) |
Congenital hip dislocation | 0.93 (0.84, 1.04) | 1.09 (0.97, 1.24) | 0.95 (0.85, 1.06) | 1.85 (1.65, 2.07) | 2.28 (2.08, 2.51) | 1.28 (0.87, 1.87) |
Small intestinal atresia/stenosis | 0.86 (0.77, 0.97) | 0.87 (0.77, 0.97) | 1.09 (0.99, 1.2) | 1.1 (1, 1.21) | 1.22 (1.12, 1.33) | 1.26 (1.14, 1.39) |
Single ventricle | 0.84 (0.66, 1.05) | 0.46 (0.36, 0.59) | 1.07 (0.93, 1.23) | 0.81 (0.7, 0.93) | 1.21 (1.06, 1.39) | 1.22 (1, 1.5) |
Deletion 22q11.2 | 0.59 (0.45, 0.77) | 1.26 (0.98, 1.6) | 2.93 (2.39, 3.58) | 1.81 (1.46, 2.25) | 1.36 (1.09, 1.68) | 1.21 (0.9, 1.64) |
Biliary atresia | 1.02 (0.87, 1.2) | 0.63 (0.51, 0.77) | 0.88 (0.74, 1.05) | 1.12 (0.94, 1.32) | 1.19 (1.02, 1.39) | 1.2 (1.02, 1.4) |
Double outlet right ventricle | 1.04 (0.92, 1.17) | 0.69 (0.6, 0.79) | 1.12 (1.01, 1.23) | 0.91 (0.82, 1.01) | 1.19 (1.08, 1.31) | 1.16 (1.01, 1.33) |
Trisomy 13 | 0.62 (0.53, 0.71) | 0.97 (0.85, 1.1) | 0.86 (0.82, 0.9) | 1.76 (1.67, 1.85) | 1.29 (1.23, 1.35) | 1.14 (1, 1.28) |
Total anomalous pulmonary venous connection | 0.62 (0.52, 0.74) | 0.62 (0.5, 0.75) | 1.44 (1.24, 1.66) | 1.31 (1.13, 1.52) | 1.05 (0.93, 1.19) | 1.13 (0.99, 1.29) |
Clubfoot | 1.02 (0.97, 1.08) | 0.88 (0.83, 0.93) | 1.03 (0.97, 1.1) | 0.99 (0.94, 1.05) | 1.07 (1.01, 1.14) | 1.1 (1.03, 1.18) |
Diaphragmatic hernia | 1.22 (1.13, 1.33) | 0.83 (0.76, 0.91) | 1.15 (1.06, 1.26) | 0.87 (0.79, 0.95) | 1.24 (1.15, 1.34) | 1.09 (1, 1.17) |
Patent ductus arteriosus | 0.96 (0.92, 1) | 0.72 (0.69, 0.75) | 1.13 (1.08, 1.18) | 0.79 (0.75, 0.82) | 0.58 (0.56, 0.6) | 1.08 (0.89, 1.3) |
Trisomy 21 (Down syndrome) | 0.83 (0.8, 0.87) | 1.03 (0.99, 1.07) | 1.02 (0.99, 1.04) | 1.13 (1.11, 1.16) | 1.14 (1.12, 1.17) | 1.06 (1.02, 1.09) |
Atrioventricular septal defect | 0.95 (0.89, 1.01) | 0.79 (0.74, 0.84) | 1.07 (1.01, 1.13) | 0.92 (0.87, 0.98) | 1.05 (1, 1.11) | 1.06 (0.99, 1.12) |
Trisomy 18 | 0.66 (0.6, 0.73) | 0.89 (0.82, 0.98) | 1.06 (1.02, 1.1) | 1.34 (1.29, 1.39) | 1.31 (1.27, 1.35) | 1.04 (0.96, 1.13) |
Cleft lip alone | 1.06 (0.96, 1.17) | 1.04 (0.94, 1.15) | 1.18 (1.08, 1.28) | 0.82 (0.75, 0.89) | 0.97 (0.9, 1.05) | 1.03 (0.93, 1.14) |
Hypoplastic left heart syndrome | 1.2 (1.1, 1.3) | 0.69 (0.62, 0.75) | 1.12 (1.04, 1.19) | 0.91 (0.85, 0.98) | 1.1 (1.03, 1.17) | 1.03 (0.95, 1.11) |
Aortic valve stenosis | 0.96 (0.87, 1.06) | 0.71 (0.64, 0.8) | 1.59 (1.48, 1.71) | 1.03 (0.96, 1.11) | 0.9 (0.84, 0.96) | 1.02 (0.93, 1.12) |
Transposition of great arteries | 1.25 (1.16, 1.36) | 0.8 (0.73, 0.87) | 1.23 (1.14, 1.32) | 0.85 (0.79, 0.91) | 1.01 (0.94, 1.09) | 1.01 (0.94, 1.09) |
Anotia/microtia | 0.37 (0.32, 0.42) | 0.87 (0.77, 0.97) | 1.38 (1.3, 1.46) | 1.62 (1.53, 1.71) | 1 (0.96, 1.05) | 1.01 (0.92, 1.1) |
Rectal and large intestinal atresia/stenosis | 1.2 (1.12, 1.28) | 0.84 (0.78, 0.9) | 1.08 (1, 1.16) | 0.87 (0.81, 0.94) | 0.9 (0.85, 0.96) | 1 (0.94, 1.07) |
Spina bifida without anencephalus | 1.04 (0.97, 1.11) | 0.83 (0.77, 0.9) | 1.36 (1.3, 1.42) | 1 (0.96, 1.05) | 1.05 (1.01, 1.09) | 1 (0.94, 1.07) |
Gastroschisis | 1 (0.94, 1.07) | 0.89 (0.83, 0.96) | 1.47 (1.39, 1.56) | 0.97 (0.91, 1.03) | 0.93 (0.88, 0.98) | 1 (0.94, 1.06) |
Cleft lip with cleft palate | 1.14 (1.06, 1.22) | 0.86 (0.79, 0.93) | 1.37 (1.28, 1.46) | 0.93 (0.87, 0.99) | 0.96 (0.9, 1.02) | 0.99 (0.92, 1.06) |
Coarctation of the aorta | 1.16 (1.09, 1.23) | 0.7 (0.66, 0.75) | 1.16 (1.1, 1.22) | 0.87 (0.82, 0.92) | 1.38 (1.32, 1.45) | 0.98 (0.93, 1.04) |
Anencephalus | 0.89 (0.81, 0.99) | 0.7 (0.63, 0.78) | 1.36 (1.29, 1.42) | 1.03 (0.99, 1.08) | 0.93 (0.89, 0.96) | 0.97 (0.88, 1.07) |
Esophageal atresia/tracheoesophageal fistula | 1.08 (0.99, 1.18) | 1.06 (0.97, 1.16) | 1.04 (0.95, 1.14) | 1.01 (0.92, 1.1) | 1.11 (1.02, 1.21) | 0.97 (0.89, 1.05) |
Tetralogy of Fallot | 1.1 (1.03, 1.17) | 0.78 (0.73, 0.84) | 1.03 (0.97, 1.1) | 0.99 (0.93, 1.05) | 0.96 (0.91, 1.02) | 0.96 (0.91, 1.03) |
Encephalocele | 1.21 (1.05, 1.39) | 0.68 (0.58, 0.81) | 1.08 (0.98, 1.18) | 0.91 (0.83, 1) | 0.94 (0.86, 1.02) | 0.96 (0.83, 1.1) |
Congenital posterior urethral valves | 1.11 (0.95, 1.29) | 0.61 (0.52, 0.71) | 1.06 (0.92, 1.23) | 0.84 (0.73, 0.97) | 1.33 (1.15, 1.54) | 0.95 (0.79, 1.14) |
Interrupted aortic arch | 1.27 (0.99, 1.62) | 0.85 (0.65, 1.11) | 1.38 (1.12, 1.69) | 0.81 (0.65, 1) | 1.04 (0.84, 1.27) | 0.93 (0.73, 1.19) |
Dextro-transposition of great arteries (d-TGA) | 1.19 (1.08, 1.33) | 0.89 (0.79, 1) | 0.96 (0.87, 1.07) | 0.89 (0.8, 0.98) | 0.75 (0.68, 0.82) | 0.93 (0.84, 1.03) |
Congenital cataract | 0.93 (0.83, 1.04) | 0.91 (0.81, 1.02) | 1.09 (0.97, 1.22) | 0.97 (0.87, 1.08) | 0.94 (0.86, 1.04) | 0.9 (0.81, 1) |
Bladder exstrophy | 1.57 (1.19, 2.05) | 0.92 (0.69, 1.24) | 1.16 (0.86, 1.57) | 0.86 (0.62, 1.18) | 1.03 (0.75, 1.4) | 0.88 (0.67, 1.17) |
Cleft palate alone | 1.23 (1.16, 1.31) | 1.01 (0.95, 1.08) | 1.16 (1.09, 1.22) | 0.97 (0.91, 1.02) | 0.96 (0.91, 1.01) | 0.88 (0.83, 0.93) |
Pyloric stenosis | 1.72 (1.63, 1.82) | 0.35 (0.32, 0.38) | 1.9 (1.8, 2.01) | 0.66 (0.62, 0.71) | 0.89 (0.84, 0.95) | 0.87 (0.75, 1.01) |
Pulmonary valve atresia and stenosis | 1 (0.95, 1.05) | 0.71 (0.67, 0.75) | 1.02 (0.97, 1.07) | 0.87 (0.83, 0.92) | 0.88 (0.84, 0.92) | 0.86 (0.82, 0.9) |
Limb deficiencies (reduction defects) | 1.09 (1, 1.19) | 0.87 (0.79, 0.95) | 1.07 (1, 1.15) | 0.85 (0.79, 0.91) | 0.77 (0.73, 0.82) | 0.85 (0.77, 0.94) |
Hydrocephalus without spina bifida | 1.34 (1.22, 1.47) | 1.03 (0.94, 1.14) | 0.87 (0.8, 0.95) | 0.97 (0.89, 1.06) | 1.05 (0.97, 1.12) | 0.84 (0.66, 1.06) |
Amniotic Bands | 0.95 (0.67, 1.33) | 0.65 (0.49, 0.86) | 1.49 (1.04, 2.13) | 0.67 (0.44, 1.03) | 0.84 (0.58, 1.23) | 0.83 (0.47, 1.49) |
Ebstein anomaly | 1.13 (0.97, 1.33) | 0.71 (0.59, 0.85) | 1.33 (1.16, 1.53) | 0.92 (0.8, 1.05) | 0.88 (0.78, 1.01) | 0.83 (0.71, 0.97) |
Choanal atresia | 1.4 (1.23, 1.58) | 1.02 (0.9, 1.17) | 0.83 (0.74, 0.93) | 0.88 (0.78, 0.99) | 0.78 (0.69, 0.87) | 0.81 (0.72, 0.92) |
Omphalocele | 1.19 (1.07, 1.31) | 0.79 (0.71, 0.87) | 1.07 (1.01, 1.15) | 0.85 (0.79, 0.91) | 0.92 (0.87, 0.98) | 0.81 (0.73, 0.89) |
Common truncus (truncus arteriosus) | 2.1 (1.8, 2.46) | 0.58 (0.48, 0.7) | 1.02 (0.87, 1.2) | 0.72 (0.61, 0.85) | 0.73 (0.63, 0.84) | 0.76 (0.65, 0.89) |
Reduction deformity, Lower limbs | 1.22 (1.03, 1.45) | 0.94 (0.78, 1.13) | 1.04 (0.88, 1.24) | 0.82 (0.69, 0.98) | 0.84 (0.72, 0.98) | 0.76 (0.47, 1.21) |
Ventricular septal defect | 1.19 (1.17, 1.22) | 0.84 (0.82, 0.86) | 0.85 (0.83, 0.87) | 0.79 (0.77, 0.81) | 0.74 (0.73, 0.76) | 0.75 (0.73, 0.77) |
Craniosynostosis | 1.27 (1.14, 1.42) | 0.61 (0.54, 0.69) | 1.12 (1.01, 1.24) | 0.98 (0.89, 1.08) | 0.54 (0.5, 0.59) | 0.75 (0.68, 0.83) |
Hypospadias | 1.59 (1.56, 1.62) | 0.87 (0.85, 0.89) | 0.98 (0.96, 1) | 1 (0.98, 1.02) | 0.74 (0.72, 0.75) | 0.73 (0.71, 0.74) |
Anophthalmia/microphthalmia | 0.79 (0.69, 0.91) | 1.03 (0.9, 1.18) | 1.18 (1.08, 1.27) | 1.17 (1.07, 1.27) | 0.59 (0.55, 0.63) | 0.72 (0.65, 0.81) |
Turner syndrome | 0.61 (0.53, 0.71) | 1.14 (1.01, 1.3) | 1.01 (0.95, 1.08) | 1.11 (1.04, 1.19) | 1.57 (1.47, 1.66) | 0.72 (0.6, 0.87) |
Microcephalus | 1.32 (1.18, 1.46) | 0.78 (0.7, 0.87) | 1.1 (0.98, 1.23) | 0.91 (0.82, 1.02) | 0.71 (0.65, 0.78) | 0.68 (0.54, 0.85) |
Holoprosencephaly | 1.92 (1.71, 2.16) | 0.56 (0.49, 0.65) | 0.85 (0.8, 0.9) | 0.39 (0.36, 0.41) | 1.24 (1.17, 1.31) | 0.65 (0.55, 0.75) |
Epispadias | 0.8 (0.62, 1.04) | 1.22 (0.92, 1.62) | 0.69 (0.53, 0.91) | 1.37 (1.04, 1.8) | 1.31 (1.03, 1.67) | 0.64 (0.46, 0.89) |
Renal agenesis/hypoplasia | 1.25 (1.17, 1.34) | 0.92 (0.86, 0.99) | 0.95 (0.9, 1) | 0.84 (0.8, 0.89) | 0.54 (0.51, 0.57) | 0.62 (0.58, 0.66) |
Atrial septal defect | 2.53 (2.49, 2.57) | 0.56 (0.54, 0.57) | 1.31 (1.29, 1.34) | 0.71 (0.7, 0.73) | 0.71 (0.7, 0.72) | 0.52 (0.51, 0.53) |
Reduction deformity, Upper limbs | 0.9 (0.79, 1.03) | 0.95 (0.83, 1.09) | 1.02 (0.9, 1.16) | 0.83 (0.73, 0.94) | 0.7 (0.63, 0.79) | 0.51 (0.38, 0.68) |
Tricuspid valve atresia and stenosis | 0.67 (0.59, 0.76) | 0.91 (0.81, 1.03) | 0.61 (0.56, 0.68) | 1.17 (1.07, 1.29) | 0.53 (0.49, 0.58) | 0.45 (0.41, 0.5) |
Aniridia | 1.24 (0.65, 2.38) | 0.34 (0.15, 0.78) | 1.84 (1.29, 2.63) | 1.72 (1.14, 2.6) | 1.45 (0.94, 2.24) | – |