Table 3 Regression Slopes for ETOPFA-Corrected Congenital Anomaly Rates by Cannabidiol Exposure

Congenital hip dislocation

Cannabidiol

298.2937

55.1100

5.4127

6.32E-07

0.2589

3.8459

29.2973

6.32E-07

9.00E+30

7.53E+19

Small intestinal atresia/stenosis

Cannabidiol

61.6605

12.7480

4.8369

3.39E-06

0.1354

1.1814

23.3954

3.39E-06

8.48E+20

3.86E+12

Biliary atresia

Cannabidiol

10.9598

2.9445

3.7222

2.43E-04

0.0480

0.3922

13.8546

2.43E-04

2.22E+11

3.48E+05

Obstructive genitourinary defect

Cannabidiol

486.0939

176.6878

2.7511

0.0072

0.0680

13.0815

7.5688

0.0072

9.69E+14

3.51E+04

Hirschsprung disease (congenital megacolon)

Cannabidiol

38.1800

14.1676

2.6949

0.0084

0.0637

1.0029

7.2624

0.0084

2.22E+15

2.67E+04

Rectal and large intestinal atresia/stenosis

Cannabidiol

26.0458

8.9678

2.9044

0.0040

0.0274

1.3051

8.4354

0.0040

1.54E+08

751.61

Esophageal atresia/tracheoesophageal fistula

Cannabidiol

13.7132

4.8352

2.8361

0.0049

0.0253

0.7108

8.0437

0.0049

8.43E+07

464.16

Diaphragmatic hernia

Cannabidiol

21.8501

7.9675

2.7424

0.0065

0.0237

1.1678

7.5207

0.0065

4.96E+07

263.36

Cleft palate alone

Cannabidiol

46.0706

20.0476

2.2981

0.0224

0.0172

2.7752

5.2811

0.0224

7.27E+06

18.43

Reduction deformity, Lower limbs

Cannabidiol

42.6901

21.4422

1.9909

0.0492

0.0288

1.6564

3.9638

0.0492

3.07E+10

2.38

Transposition of great arteries

Cannabidiol

19.6282

9.8766

1.9873

0.0479

0.0106

1.4902

3.9496

0.0479

3.21E+05

1.71

Cloacal exstrophy

Cannabidiol

76.8088

39.8261

1.9286

0.0563

0.0231

2.7733

3.7195

0.0563

1.76E+11

1.00

Epispadias

Cannabidiol

19.8920

10.4475

1.9040

0.0604

0.0307

0.7526

3.6252

0.0604

5.58E+10

1.00

Clubfoot

Cannabidiol

123.4731

76.7503

1.6088

0.1102

0.0123

5.7575

2.5881

0.1102

5.98E+08

1.00

Deletion 22q11.2

Cannabidiol

11.7674

7.4174

1.5865

0.1154

0.0128

0.5307

2.5169

0.1154

1.16E+09

1.00

Pulmonary valve atresia

Cannabidiol

14.2898

9.1696

1.5584

0.1208

0.0075

1.0200

2.4285

0.1208

6.89E+05

1.00

Aniridia

Cannabidiol

11.4134

7.6646

1.4891

0.1403

0.0146

0.4236

2.2174

0.1403

8.91E+10

1.00

Cleft lip with and without cleft palate

Cannabidiol

47.9755

35.6346

1.3463

0.1812

0.0078

2.8627

1.8126

0.1812

8.40E+06

1.00

Hypospadias

Cannabidiol

215.6799

160.8491

1.3409

0.1811

0.0029

24.1209

1.7980

0.1811

6.84E+03

1.00

Interrupted aortic arch

Cannabidiol

12.3060

10.7579

1.1439

0.2546

0.0022

0.8940

1.3085

0.2546

5.51E+05

1.00

Cleft lip with cleft palate

Cannabidiol

18.8934

17.5531

1.0764

0.2832

8.75E-04

1.8366

1.1585

0.2832

2.33E+04

1.00

Bladder exstrophy

Cannabidiol

1.2975

1.2080

1.0741

0.2838

6.22E-04

0.1585

1.1537

0.2838

3.44E+03

1.00

Total anomalous pulmonary venous connection

Cannabidiol

4.1211

4.3730

0.9424

0.3473

−6.29E-04

0.5022

0.8881

0.3473

3.50E+03

1.00

Congenital cataract

Cannabidiol

4.4981

7.4397

0.6046

0.5460

−0.0024

1.0520

0.3655

0.5460

97.42

1.00

Dextro-transposition of great arteries (d-TGA)

Cannabidiol

5.4634

9.0926

0.6009

0.5487

−0.0036

1.0480

0.3610

0.5487

229.30

1.00

Aortic valve stenosis

Cannabidiol

9.0139

15.8331

0.5693

0.5696

−0.0025

2.1657

0.3241

0.5696

87.79

1.00

Microcephalus

Cannabidiol

25.8143

51.1470

0.5047

0.6150

−0.0082

3.7981

0.2547

0.6150

970.31

1.00

Cleft lip alone

Cannabidiol

10.5197

24.3612

0.4318

0.6664

−0.0045

2.3987

0.1865

0.6664

107.70

1.00

Tetralogy of Fallot

Cannabidiol

4.4464

10.6210

0.4186

0.6758

−0.0029

1.6091

0.1753

0.6758

24.21

1.00

Patent ductus arteriosus

Cannabidiol

104.0952

399.2821

0.2607

0.7950

−0.0114

28.5501

0.0680

0.7950

54.70

1.00

Congenital posterior urethral valves

Cannabidiol

2.4488

20.4918

0.1195

0.9050

−0.0069

1.6854

0.0143

0.9050

6.96

1.00

Ventricular septal defect

Cannabidiol

−23.7333

139.2946

−0.1704

0.8648

−0.0037

20.2028

0.0290

0.8648

5.27

NA

Choanal atresia

Cannabidiol

−1.0493

5.0746

−0.2068

0.8363

−0.0036

0.7189

0.0428

0.8363

7.01

NA

Limb deficiencies (reduction defects)

Cannabidiol

−9.2029

28.6458

−0.3213

0.7484

−0.0051

2.6608

0.1032

0.7484

46.05

NA

Single ventricle

Cannabidiol

−3.9066

11.5847

−0.3372

0.7364

−0.0059

0.9895

0.1137

0.7364

72.15

NA

Pulmonary valve atresia and stenosis

Cannabidiol

−22.4845

34.4394

−0.6529

0.5144

−0.0021

5.0837

0.4262

0.5144

111.44

NA

Gastroschisis

Cannabidiol

−9.7272

13.2026

−0.7368

0.4619

−0.0018

1.9055

0.5428

0.4619

207.72

NA

Coarctation of the aorta

Cannabidiol

−27.6410

27.9781

−0.9880

0.3240

−8.62E-05

4.2271

0.9760

0.3240

767.41

NA

Common truncus (truncus arteriosus)

Cannabidiol

−9.2806

8.3564

−1.1106

0.2677

8.54E-04

1.1939

1.2334

0.2677

2.36E+03

NA

Anophthalmia/microphthalmia

Cannabidiol

−14.7546

12.6122

−1.1699

0.2431

0.0014

1.7384

1.3686

0.2431

4.52E+03

NA

Encephalocele

Cannabidiol

−11.9747

9.2992

−1.2877

0.1989

0.0024

1.3294

1.6582

0.1989

7.26E+03

NA

Atrial septal defect

Cannabidiol

−610.8850

361.7188

−1.6888

0.0925

0.0071

52.7719

2.8522

0.0925

7.52E+04

NA

Atrioventricular septal defect

Cannabidiol

−31.8080

16.5300

−1.9243

0.0554

0.0099

2.4231

3.7028

0.0554

3.08E+05

NA

Hydrocephalus without spina bifida

Cannabidiol

−56.5887

54.7420

−1.0337

0.3040

7.37E-04

4.0806

1.0686

0.3040

6.05E+05

NA

Holoprosencephaly

Cannabidiol

−146.0616

130.5839

−1.1185

0.2652

0.0017

10.2919

1.2511

0.2652

8.12E+05

NA

Turner syndrome

Cannabidiol

−103.2404

93.9159

−1.0993

0.2736

0.0015

7.1498

1.2084

0.2736

1.02E+06

NA

Hypoplastic left heart syndrome

Cannabidiol

−21.8275

9.7759

−2.2328

0.0263

0.0137

1.4903

4.9854

0.0263

1.23E+06

NA

Amniotic Bands

Cannabidiol

−8.5621

9.9023

−0.8647

0.3909

−0.0044

0.5072

0.7476

0.3909

9.39E+06

NA

Double outlet right ventricle

Cannabidiol

−17.4959

10.8027

−1.6196

0.1073

0.0099

1.0255

2.6230

0.1073

1.11E+07

NA

Anotia/microtia

Cannabidiol

−75.4583

28.5853

−2.6398

0.0088

0.0215

4.1677

6.9683

0.0088

2.86E+07

NA

Renal agenesis/hypoplasia

Cannabidiol

−55.5432

21.1694

−2.6237

0.0092

0.0213

3.0263

6.8841

0.0092

3.59E+07

NA

Omphalocele

Cannabidiol

−72.7238

25.9206

−2.8056

0.0054

0.0273

3.5964

7.8716

0.0054

1.96E+08

NA

Tricuspid valve atresia and stenosis

Cannabidiol

−66.1395

18.6247

−3.5512

4.53E-04

0.0414

2.7738

12.6108

4.53E-04

5.30E+09

NA

Spina bifida without anencephalus

Cannabidiol

−100.5390

26.3548

−3.8148

1.67E-04

0.0446

4.0223

14.5529

1.67E-04

1.51E+10

NA

Trisomy 21 (Down syndrome)

Cannabidiol

−294.7787

68.5834

−4.2981

2.36E-05

0.0568

10.4764

18.4737

2.36E-05

2.64E+11

NA

Trisomy 13

Cannabidiol

−159.8606

36.7241

−4.3530

1.90E-05

0.0617

5.3524

18.9488

1.90E-05

1.27E+12

NA

Ebstein anomaly

Cannabidiol

−13.6797

3.1851

−4.2949

2.46E-05

0.0620

0.4446

18.4464

2.46E-05

2.90E+12

NA

Reduction deformity, Upper limbs

Cannabidiol

−50.5739

20.4153

−2.4773

0.0150

0.0493

1.5707

6.1368

0.0150

1.06E+13

NA

Craniosynostosis

Cannabidiol

−128.6709

60.4738

−2.1277

0.0361

0.0369

3.7943

4.5272

0.0361

5.05E+13

NA

Trisomy 18

Cannabidiol

−376.7155

67.6238

−5.5708

5.95E-08

0.0966

10.0334

31.0333

5.95E-08

1.38E+15

NA

Anencephalus

Cannabidiol

−405.9858

49.6283

−8.1805

9.98E-15

0.1900

7.0466

66.9210

9.98E-15

1.18E+23

NA