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Table 23 Obstructive Genitourinary Defects - E-Values from Mixed Effects and Panel Regression Models

From: Geotemporospatial and causal inference epidemiological analysis of US survey and overview of cannabis, cannabidiol and cannabinoid genotoxicity in relation to congenital anomalies 2001–2015

Parameter

Estimate (C.I.)

R.R. (C.I.)

E-Values

MIXED EFFECTS MODELS

Cannabis Only

  Cannabis

14.35 (8.44, 20.27)

94.85 (15.13, 594.66)

189.20, 29.75

Additive Model - Drugs

  Cannabis

14.35 (8.44, 20.27)

94.85 (15.13, 594.66)

189.20, 29.75

Interactive Model - Drugs

  Cigarettes: Cannabis: Analgesics

333.48 (176.14, 490.83)

1.62E+51 (4.54E+27, 5.81E+74)

3.25E+51, 9.09E+27

  Cannabis: Bng.Alcohol: Analgesics

700.3 (368.06, 1032.54)

3.47E+107 (6.41E+57, 1.88E+157)

6.94E+107, 1.29E+58

  Cannabis: Bng.Alcohol

921.93 (370.26, 1473.6)

3.75E+1241 (9.87E+58, 1.43E_224)

7.51E+141, 1.97E+59

Additive Model - Cannabinoids

  THC

43.47 (8.06, 78.89)

1.72E+06 (18.61, 1.59E+11)

3.43E+06, 36.72

Interactive Model - Cannabinoids

  Cigarettes: THC

1945.4 (832.31, 3058.5)

2.73E+296 (5.73E+130, Infinity)

Infinity, 1.14E+131

  Cigarettes: THC: CBG

482.22 (204.16, 760.28)

3.02E+73 (1.23E+32, 7.37E+114)

6.04E+73, 2.46E+32

Additive Model - Including Sociodemographics

  THC

11.62 (7.82, 15.42)

58.96 (16.01, 217.10)

117.42, 31.52

Interactive Model - Including Sociodemographics

  THC: CBG

918.55 (286.58, 1550.52)

2.27E+138 (4.07E+45, 1.27E+231)

4.55E+138, 8.15E+45

  THC: CBG: CBD

248.54 (72.69, 424.4)

2.73E+37 (4.24E+11, 1.76E+63)

5.46E+37, 8.49E+11

  THC

3517.29 (910.69, 6123.89)

Infinity (1.78E+147, Infinity)

Infinity, 3.57E+147

  THC: CBD

946.55 (214.43, 1678.68)

3.75E+142 (1.34E+35, 1.05E+250)

7.51E+142, 2.69E+35

PANEL MODELS

Interactive Model - Including Sociodemographics

  THC

7726.08 (3068.06, 12,384.1)

Infinity (9.29E+186, Infinity)

Infinity, Infinity

  THC: CBD

2899.61 (1040.91, 4758.31)

1.47E+176 (2.93E+63, 7.39E+288)

Infinity, 5.86E+63

  THC: CBG: CBD

202.14 (44.72, 359.56)

1.91E+12 (545.0179, 6.69E+21)

3.82E+12, 1.09E+03

Sociodemographic Interactive Model - 1 Lag

  Cigarettes: THC: CBD

163.56 (80.31, 246.82)

4.75E+08 (1.85E+04, 1.21E+13)

9.50E+08, 3.71E+04

  Cigarettes: THC

719.66 (347.71, 1091.61)

1.50E+38 (3.05E+18, 7.39E+57)

3.01E+38, 6.11E+18

Additive Model - Drugs

  Cannabis

10.61 (4.7, 16.52)

5.66E+19 (8.37E+08, 3.82E+30)

1.13E+20, 1.67E+09

Interactive Model - Drugs

  Cannabis

10.61 (4.7, 16.52)

44.75 (5.40, 370.45)

89.06, 10.29

Interactive Model - Drugs, 2 Lags

  Cannabis

241.68 (65.24, 418.12)

3.25E+08 (204.43, 5.18E+14)

6.51E+08, 408.35

THC

  THC

8.14 (4.27, 12)

19.67 (4.78, 80.93)

38.84, 9.03

Cannabigerol

  Cannabigerol

7.54 (3.14, 11.94)

14.30 (3.04, 67.26)

28.10, 5.53

Additive Model - Drugs & Cannabinoids

  THC

8.14 (4.27, 12)

18.91 (4.68, 76.34)

37.31, 8.84

Interactive Model - Drugs & Cannabinoids

  THC

8.14 (4.27, 12)

19.67 (47.78, 80.94)

38.84, 9.04

1 Spatial Lag - Interactive Model, THC * CBD

  Cigarettes: CBD

792.04 (292.87, 1291.2)

2.15E+125 (3.19E+46, 1.45E+204)

4.31E+125, 6.39E+46

  Cigarettes: THC: CBD

912.27 (282.87, 1541.68)

2.29E+144 (9.107E+44, 5.77E+243)

4.58E+144, 1.83E+45

  Cigarettes: THC

3167.74 (941.61, 5393.88)

Infinity (5.16E+149, Infinity)

Infinity, 1.03E+150

1 Spatial Lag - Interactive Model, THC * CBG

  Cigarettes: THC: CBG

855.74 (286.28, 1425.2)

8.09E+135 (4.45E+45, 1.47E+226)

1.61E+136, 8.91E+45

  Cigarettes: THC

2980.74 (841.4, 5120.08)

Infinity (2.06E+134, Infinity)

Infinity, 4.14E+134

  Cigarettes: CBG

755.71 (171.07, 1340.34)

1.05E+120 (2.27E+27, 4.83E+212)

2.09E+120, 4.54E+27

1 Spatial, 1 Temporal Lag Cannabinoids

  Cigarettes: THC: CBD

1394.48 (386.59, 2402.38)

4.17E+192 (4.79E+53, Infinity)

Infinity, 9.59E+53

  Cigarettes: THC: THC.Spatial: CBD

1384.11 (374.49, 2393.72)

1.53E+1981 (1.02E+52, Infinity)

Infinity, 2.05E+52

  Cigarettes: THC

5000.58 (1323.37, 8677.78)

Infinity (6.65E+183, Infinity)

Infinity, Infinity

  Cigarettes: THC: THC.Spatial

4975.93 (1182.67, 8769.19)

Infinity (2.62E+164, Infinity)

Infinity, Infinity

  Cigarettes: CBD

522.98 (44.27, 1001.7)

1.74E+72 (1.77E+06, 1.70E+138)

3.47E+72, 3.54E+06

1 Spatial, 2 Temporal Lags Cannabinoids

  Cigarettes: CBD

48,350.5 (20,095.92, 76,605.08)

Infinity (Infinity, Infinity)

Infinity, Infinity

  Cigarettes: THC

217,699.3 (89,605.46, 345,793.14)

Infinity (Infinity, Infinity)

Infinity, Infinity

  Cigarettes: THC: CBD

76,973.5 (31,232.59, 122,714.41)

Infinity (Infinity, Infinity)

Infinity, Infinity

  THC

11,707.8 (4631.81, 18,783.79)

Infinity (1.01E+190, Infinity)

Infinity, Infinity

  THC: THC.Spatial

19,063 (7395.32, 30,730.68)

Infinity (2.51E+303, Infinity)

Infinity, Infinity

Interactive Model - Including Sociodemographics

  THC

37.58 (9.36, 65.79)

1.86E+06 (37.31, 9.29E+10)

3.72E+06, 74.13

  THC: CBG

6.95 (0.33, 13.56)

14.44 (1.14, 1852.37)

28.36, 1.54

Sociodemographic Interactive, 1 Lag

  Cigarettes: THC

46.25 (16.84, 75.67)

3.85E+05 (109.80, 1.35E+09)

7.71E+05, 219.10

Sociodemographic Interactive, 2 Lags

  Cigarettes: THC: CBD

6151.83 (2693.75, 9609.91)

1.63E+301 (1.72E+132, Infinity)

Infinity, 3.45E+132

  Cigarettes: THC

22,951.53 (9883.29, 36,019.77)

Infinity (Infinity, Infinity)

Infinity, Infinity

  Cigarettes: CBD

4078.6 (1248.29, 6908.9)

5.02E+199 (2.51E+61, Infinity)

Infinity, 5.02E+61