Table 2 Clinical features for surgical and medical NEC patients
Surgical NEC (n = 350) | Medical NEC (n = 273) | P | Unadjusted OR [95%CI] | P | Adjusted OR [95%CI] | |
|---|---|---|---|---|---|---|
NEC onset days (median [IQR]) | 10 [7–15] | 15 [9–21] | 0.007 | 0.90 [0.83–0.97] | 0.003 | 0.85 [0.77–0.95] |
Time until first defecation days (median [IQR]) | 2 [1–3] | 2 [1–4] | 0.716 | 0.95 [0.72–1.26] | ||
Late onset sepsis < 72 h prior to clinical onset (n [%]) | 204 [58.3] | 85 [31.1] | 0.022 | 3.11 [1.18–8.21] | ||
Hemodynamically significant PDA (n [%]) | 187 [53.4] | 59 [21.6] | 0.007 | 4.14 [1.46–11.69] | 0.003 | 7.60 [2.03–28.47] |
RBC transfusion days (median [IQR]) | 1 [1–2] | 1 [0–3] | 0.619 | 0.92 [0.67–1.27] | ||
Mechanic ventilation exposure (n [%]) | 256 [73.1] | 153 [56.0] | 0.134 | 2.12 [0.79–5.67] | ||
Mechanic ventilation days (median [IQR]) | 4 [1–6] | 3 [0–9] | 0.767 | 1.01 [0.92–1.11] | ||
Enteral feeding type (n [%]) | ||||||
Breast milk | 139 [39.7] | 112 [41.0] | 0.346 | Reference | ||
Formula milk | 42 [12.0] | 8 [2.9] | 0.211 | 4.29 [0.44–41.95] | ||
Combination | 169 [48.3] | 153 [56.1] | 0.682 | 0.80 [0.28–2.28] | ||
Achieved full enteral feeding (n [%]) | 128 [36.5] | 170 [62.3] | 0.030 | 0.35 [0.13–0.90] | ||
Total days parenteral feeding (median [IQR]) | 9 [5–13] | 9 [5–12] | 0.894 | 1.01 [0.90–1.13] | ||
Postpartum antibiotics (n [%]) | ||||||
Not administered | 25 [7.1] | 76 [27.8] | 0.081 | Reference | ||
1–3 days administered | 187 [53.4] | 119 [43.6] | 0.038 | 4.71 [1.09–20.47] | ||
> 3 days administered | 138 [39.5] | 78 [28.6] | 0.033 | 5.33 [1.14–24.90] | ||
Antibiotics days (median [IQR]) | 5 [3–9] | 6 [3–8] | 0.844 | 0.99 [0.89–1.11] | ||
Medication (n [%]) | ||||||
Antimycotics | 76 [21.7] | 51 [18.7] | 0.737 | 1.22 [0.38–3.87] | ||
Corticosteroids | 42 [12.0] | 25 [9.2] | 0.703 | 1.34 [0.30–6.09] | ||
Inotropes | 128 [36.6] | 51 [18.7] | 0.100 | 2.50 [0.84–7.45] | ||