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Table 2 Endocrine and exocrine pancreatic functions in TDT children according to their zinc status

From: The effect of zinc deficiency and iron overload on endocrine and exocrine pancreatic function in children with transfusion-dependent thalassemia: a cross-sectional study

Variables

Low serum zinc

N = 44

Normal serum zinc

N = 36

p

Odds ratio (95% CI)

I. Endocrine pancreatic function

1) OGTT

    

Impaired: n (%)

12 (27.3%)

2 (5.6%)

0.01*

6.4 (1.3–30.7)

2) Insulin (μIu/ml):

    

Mean ± SD

15.4 ± 0.7

12.6 ± 5.8

0.4

 

High: n (%)

32 (72.7%)

16 (44.4%)

0.07

0.88 (0.7–1.04)

3) HOMA-IR

    

Mean ± SD

3.32 ± 3.37

2.7 ± 1.55

0.4

 

High: n (%)

24 (54.5%)

8 (22.2%)

0.03*

4.2 (1.08–16.6)

II. Exocrine pancreatic function

1) Serum amylase (Iu/ml):

    

Mean ± SD

61.95 ± 16.69

61.13 ± 20.8

0.8

 

Low: n (%)

14 (31.8%)

12 (33.3%)

0.1

0.79 (0.21–2.9)

2) Serum lipase (u/l):

    

Mean ± SD

40.23 ± 9.91

31.75 ± 4.9

< 0.001*

 

High: n (%)

24 (54.5%)

4 (11.1%)

< 0.001*

9.6 (2.9–31.8)

  1. CI confidence interval; OGTT Oral glucose tolerance test; HOMA-IR Homeostatic model assessment of insulin resistance
  2. * Statistical significance< 0.05