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Table 2 Endocrine and exocrine pancreatic functions in TDT children according to their zinc status

From: The effect of zinc deficiency and iron overload on endocrine and exocrine pancreatic function in children with transfusion-dependent thalassemia: a cross-sectional study

Variables Low serum zinc
N = 44
Normal serum zinc
N = 36
p Odds ratio (95% CI)
I. Endocrine pancreatic function
1) OGTT     
Impaired: n (%) 12 (27.3%) 2 (5.6%) 0.01* 6.4 (1.3–30.7)
2) Insulin (μIu/ml):     
Mean ± SD 15.4 ± 0.7 12.6 ± 5.8 0.4  
High: n (%) 32 (72.7%) 16 (44.4%) 0.07 0.88 (0.7–1.04)
3) HOMA-IR     
Mean ± SD 3.32 ± 3.37 2.7 ± 1.55 0.4  
High: n (%) 24 (54.5%) 8 (22.2%) 0.03* 4.2 (1.08–16.6)
II. Exocrine pancreatic function
1) Serum amylase (Iu/ml):     
Mean ± SD 61.95 ± 16.69 61.13 ± 20.8 0.8  
Low: n (%) 14 (31.8%) 12 (33.3%) 0.1 0.79 (0.21–2.9)
2) Serum lipase (u/l):     
Mean ± SD 40.23 ± 9.91 31.75 ± 4.9 < 0.001*  
High: n (%) 24 (54.5%) 4 (11.1%) < 0.001* 9.6 (2.9–31.8)
  1. CI confidence interval; OGTT Oral glucose tolerance test; HOMA-IR Homeostatic model assessment of insulin resistance
  2. * Statistical significance< 0.05