Table 1 Key questions for vitamin D prophylaxis in infancy
Key question 1 | Key question 2 | Key question 3 | |
|---|---|---|---|
Participants | Infants | Infants | Infants without risk factors Infants with risk factors |
Intervention | Vitamin D supplement at any dose | Dose A of vitamin D | Vitamin D supplement until 12 months of age |
Comparison | Placebo or no vitamin D supplement | Dose B of vitamin D | Vitamin D supplement until more than 12 months of age |
Outcomes | Clinical outcomes: rickets (clinical or radiological signs), infections Anthropometric outcomes such as mineral bone density Levels of serum vitamin D (25OHD) | ||
Adverse effects | Any adverse effect | ||