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Table 5 Impact of parental consanguinity on family history of cancer and number of relatives with cancer

From: Implications of ACMG guidelines to identify high-risk acute lymphoblastic leukemia patients with hereditary cancer susceptibility syndromes (HCSS) in a highly consanguineous population

 

Parental consanguinity

OR (95% CI)

P-value

YES (N = 151)

NO (N = 147)

Family history of cancer

 Yes

37 (24.50%)

29 (19.73%)

1.32 (0.76–1.29)

0.32

 No

114 (75.49%)

118 (80.27%)

 First degree relatives

4 (10.81%)

1 (3.45%)

4.14 (0.45–37.60)

 Second degree relatives

25 (67.57%)

22 (68.96%)

1.18 (0.62–2.20)

0.61

 Third degree relatives

10 (27.03%)

6 (20.69%)

1.72 (0.60–4.90)

0.30

 First and second degree relatives

29 (78.37%)

22 (75.86%)

1.31 (0.71–2.43)

0.38

Number of relatives with cancer

 1

141(93.37%)

142 (96.59%)

0.49 (0.16–1.48)

0.20

 ≥ 1

10 (6.62%)

5 (3.40)