Table 4 Impact of familial history on the characteristics and type of ALL patients with no associated disorder
Characteristics | Familial history of disease (n = 66) | No familial history of disease (n = 232) | Odds ratio (95% CI) | P-value |
|---|---|---|---|---|
Age of the patient | ||||
< 10 | 49 (74.24%) | 179 (77.15%) | 0.85 (0.45–1.60) | 0.62 |
≥ 10 | 17 (25.75%) | 53 (22.84%) | ||
WBC count | ||||
< 50,000 | 65 (98.48%) | 220 (94.82) | 3.54 (0.45–27.78) | – |
≥ 50,000 | 1(1.51%) | 12 (5.17) | ||
Hepatospleenomegaly | ||||
Yes | 21 (31.81%) | 86 (37.06%) | 0.79 (0.44–1.41) | 0.43 |
No | 45 (68.18%) | 146 (62.93) | ||
Cardiotoxicity | ||||
Yes | 13 (19.69%) | 21 (21.98%) | 2.46 (1.15–5.24) | 0.02* |
No | 53 (80.30%) | 211 (90.94) | ||
Sub-type of ALL | ||||
Pre-BALL | 57 (86.36%) | 200 (86.20%) | 1.01 (0.45–1.24) | 0.86 |
Pre-TALL | 9 (13.63%) | 32 (13.79%) | ||
BCR-ABL translocation | 0 (0.00) | 1 (0.43%) | – | – |
Two primary cancers in the affected child | 0 (0.00) | 1 (0.43%) | – | – |