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Table 1 General characteristics of individuals in the obesity cohort

From: Prevalence of increased transaminases and its association with sex, age, and metabolic parameters in children and adolescents with obesity – a nationwide cross-sectional cohort study

Variables

Total

Normal ALT

Mildly increased ALT

Markedly increased ALT

P value1

P value2

P value3

>URL to < 2 x URL

≥2 x URL

n = 11,776

n = 6070

n = 4461

n = 1245

Males, n(%)

6300 (53.5)

3250 (53.5)

2220 (49.8)

830 (66.7)

< 0.001

< 0.001

< 0.001

Age (years), mean (SD)

11.0 (3.3)

10.7 (3.3)

11.1 (3.3)

12.5 (3.3)

< 0.001

< 0.001

< 0.001

 5- < 8 years, n(%)

2574 (21.9)

1526 (25.1)

931 (20.9)

117 (9.4)

   

 8- < 11 years, n(%)

3427 (29.1)

1761 (29.0)

1365 (30.6)

301 (24.2)

   

 11- < 14 years, n(%)

3077 (26.1)

1603 (26.4)

1123 (25.2)

351 (28.2)

   

 14- < 18 years, n(%)

2698 (22.9)

1180 (19.4)

1042 (23.4)

476 (38.2)

   

Degree of obesity

 Class I obesity, n(%)

6629 (56.3)

3815 (62.8)

2265 (50.8)

549 (44.1)

< 0.001

< 0.001

< 0.001

 Class II obesity, n(%)

3345 (28.4)

1553 (25.6)

1386 (31.1)

406 (32.2)

   

 Class III obesity, n(%)

1802 (15.3)

702 (11.6)

810 (18.2)

290 (23.3)

   
  1. Abbreviations: ALT alanine aminotransferase, SD standard deviation, URL upper reference level
  2. Differences between groups were assessed using the chi-square test or independent t-test, where appropriate
  3. 1 Comparison between mildly increased ALT and normal ALT group
  4. 2 Comparison between markedly increased ALT and normal ALT group
  5. 3 Comparison between markedly increased ALT and mildly increased ALT group