Neonatal Outcomes | Maternal 25(OH)D status(nmol/L) | χ2/F/H P-value | |||
---|---|---|---|---|---|
 | < 50 (N = 15,696) | 50–75 (N = 6981) | > 75 (N = 717) | Total (N = 23,394) |  |
Birth weight (Mean ± SD) | 3346 ± 448 | 3340 ± 437 | 3329 ± 412 | 3343 ± 443 | .833 .435& |
Birth weight z score (Mean ± SD) | .005 ± 1.010 | −.008 ± .985 | −.032 ± .928 | – |  |
Low birth weight: < 2500 g | 372(2.4) | 141(2.0) | 14(2.0) | 527(2.3) | 2.995 .224* |
Very low birth weight: < 1500 g | 42(0.3) | 20(0.3) | 1(0.1) | 63(0.3) | 0.529 .768* |
Small for gestational age: <10th percentile (3 case excluded) | 322(2.1) | 135(1.9) | 15(2.1) | 472(2.0) | 1.833 .766* |
High birth weight: > 4000 g | 955(6.1) | 390(5.6) | 38(5.3) | 1383(5.9) | 2.650 .266* |
Large for gestational age: >90th percentile | 3679(23.4) | 1612(23.1) | 160(22.3) | 5451(23.3) | 2.212 .697* |
Birth length (Mean ± SD) | 49.9 ± 1.4 | 49.8 ± 1.4 | 49.9 ± 1.1 | 49.9 ± 1.4 | .689 .502& |
Apgar score (Mean ± SD) | 9.7 ± .9 | 9.7 ± 1.0 | 9.7 ± .8 | 9.7 ± .9 | 1.938 .144& |
Apgar score | Â | Â | Â | Â | 7.144 .308* |
0–3 | 28(.2) | 17(.2) | 0 | 45(.2) | – |
4–6 | 106(.7) | 43(.6) | 2(.3) | 151(.6) |  |
7–8 | 270(1.7) | 137(2.0) | 9(1.3) | 416(1.8) |  |
9–10 | 15,292(97.4) | 6784(97.2) | 706(98.5) | 22,782(97.4) |  |
Admission to neonatal intensive care unit | 1918(12.2) | 761(10.9) | 67(9.3) | 2746(11.7) | 12.200 .002* |
Admission to neonatal intensive care unit (Mean ± SD) | 6.2 ± 4.1 | 5.9 ± 3.1 | 5.1 ± 2.1 | 6.1 ± 3.2 | .010# |
Any respiratory disorders¶ | 334(2.1) | 131(1.9) | 16(2.2) | 481(2.1) | 1.205 .300* |
Dyspnea (clinical diagnosis) | 8(0.1) | 5(0.1) | 0 | 13(0.1) | .782 .676* |
Wet lung | 266(1.7) | 107(1.5) | 13(1.8) | 386(1.6) | .902 .637* |
Aspiration pneumonia | 5 | 3 | 0 | 8 | – |
Pulmonary arterial hypertension | 2 | 0 | 0 | 2 | – |
Pneumothorax | 30(0.2) | 6(0.1) | 1(0.1) | 37(0.2) | 3.402 .183* |
Bronchopulmonary dysplasia | 2 | 0 | 0 | 2 | – |
Neonatal convulsion | 6 | 6 | 1 | 13 | – |
Hyperbilirubinemia | 971(6.2) | 434(6.2) | 30(4.2) | 1435(6.1) | 4.487 .087* |
Necrotizing enterocolitis | 79(0.5) | 26(0.4) | 4(0.6) | 109(0.5) | 1.919 .383* |
Sepsis | 29(0.2) | 14(0.2) | 2(0.3) | 45(0.2) | – |
Retinopathy of prematurity | 19 | 7 | 0 | 26 | – |
Neonatal death | 1 | 1 | 0 | 2 | – |