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Table 3 The associations between serum bilirubin level and different types of UGT1A1 mutation and genotypes adjusted by age, gender, and feeding practice: Linear regression analysis (N = 59a)

From: UGT1A1 mutation association with increased bilirubin levels and severity of unconjugated hyperbilirubinemia in ABO incompatible newborns of China

Genotypes

TBIL

IBIL

 

ORadjb (95%CI)

P

ORadjb (95%CI)

P

TATA box

 TA6/TA6

0.00

0.57

0.00

0.58

 TA6/TA7

30.0(−73.1–133.2)

27.6(−70.4–125.5)

c.211 G > A

 G/G

0.00

0.019

0.00

0.02

 G/A-A/A

78.2(14.7–141.8)

73.3(12.8–133.7)

c.1091 C > T

 C/C

0.00

0.16

0.00

0.14

 C/T

103.1(−39.8–245.9)

103.6(−31.7–238.9)

Haplotypec (Frequency)

 TA6GC(75.85%)

0.00

 

0.00

 

 TA6AC(16.53%)

84.0(23.2–144.8)

0.0092

79.0(21.4–136.6)

0.0097

 TA7GC(5.08%)

70.4(−26.8–167.7)

0.16

65.6(−26.6–157.9)

0.17

 TA6GT(2.12%)

107.9(93.7–122.1)

< 0.0001

107.01(93.6–120.4)

< 0.0001

 TA6AT(0.42%)

149.9(147.3–152.6)

< 0.0001

152.4(150.0–154.8)

< 0.0001

  1. a Ten cases with the feeding practice unknown were not taken into the regression analysis
  2. bAdjusted for age, gender, and feeding practice
  3. cpolymorphisms are in order of: rs8175347-rs4148323-rs34946978
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BMC Pediatrics

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