Th cytokine profile in childhood-onset systemic lupus erythematosus

BMC Pediatrics

Table 4 Clinical and laboratory factors potentially associated with different variables

Variables	B	SE	P value
SLEDAI-2 K scores
IL-2	0.036	0.016	0.039*
gender	3.573	2.430	0.154
age	−0.116	0.372	0.757
Prednisone	1.934	3.278	0.561
Hydroxychloroquine	0.378	2.475	0.880
Cyclophosphamide	−2.161	2.490	0.394
Mycophenolate mofetil	−1.946	3.326	0.564
Methotrexate	−8.689	5.906	0.154
IL-6	0.050	0.019	0.016*
gender	4.097	2.376	0.097
age	−0.276	0.366	0.454
Prednisone	2.606	3.199	0.423
Hydroxychloroquine	0.724	2.415	0.767
Cyclophosphamide	−3.712	2.427	0.139
Mycophenolate mofetil	−0.825	3.217	0.800
Methotrexate	−9.794	5.738	0.101
IL-10	0.171	0.077	0.036*
gender	4.336	2.520	0.099
age	0.165	0.401	0.685
Prednisone	1.602	3.349	0.637
Hydroxychloroquine	2.318	2.898	0.432
Cyclophosphamide	−3.114	2.549	0.234
Mycophenolate mofetil	−2.926	3.542	0.417
Methotrexate	−7.625	6.033	0.219
CD4⁺/CD8⁺
IL-6	−0.003	0.002	0.045*
gender	0.102	0.185	0.586
age	0.018	0.027	0.509
Prednisone	0.319	0.213	0.148
Hydroxychloroquine	−0.046	0.199	0.821
Cyclophosphamide	−0.257	0.192	0.193
Mycophenolate mofetil	−0.192	0.277	0.495
Methotrexate	0.279	0.429	0.521
IFN-γ	−0.002	0.001	0.025*
gender	−0.341	0.191	0.859
age	0.046	0.023	0.063
Prednisone	0.070	0.214	0.746
Hydroxychloroquine	0.061	0.179	0.738
Cyclophosphamide	−0.214	0.167	0.213
Mycophenolate mofetil	−0.022	0.237	0.927
Methotrexate	0.296	0.379	0.443
Nephritis
IL-6	0.003	0.001	0.036*
gender	0.007	0.189	0.970
age	−0.056	0.029	0.064
Prednisone	0.156	0.237	0.516
Hydroxychloroquine	−0.054	0.206	0.795
Cyclophosphamide	−0.087	0.202	0.671
Mycophenolate mofetil	0.344	0.301	0.263
Methotrexate	−0.056	0.445	0.901

Continuous variables were log-transformed in the linear regression analyses, there was no multicollinearity among different variables
SE standard error; *P < 0.05

ISSN: 1471-2431