Factors associated with neurodevelopment in preterm infants with systematic inflammation

BMC Pediatrics

Table 4 Correlation between Neurologic Markers during Admission and Neurodevelopment (CA of 18 months) in the Inflammation Group

	aEEG at Day 0			aEEG at PMA 35 weeks			Brain WMI^¶ at discharge	Head circumference at 36 weeks
	Maturation score	Seizure spike^a	Voltage base^b	Maturation score	Seizure spike^a	Voltage base^b	Brain WMI^¶ at discharge	Head circumference at 36 weeks
Bayley score
Cognitive	0.124	0.040 (0.052)	− 0.269	0.283	*0.376 (0.034)**	−0.133	*− 0.371 (0.020)**	0.193
Language	−0.127	0.171	−0.102	0.246	*0.408 (0.021)**	−0.293	− 0.271	0.210
Motor	0.141	*0.581 (0.007)**	−0.269	0.161	0.227	0.030	*−0.431 (0.006)**	*0.345 (0.032)**
Social emotional	0.024	*0.544 (0.013)**	−0.175	0.206	*0.356 (0.045)**	−0.098	*− 0.350 (0.029)**	0.177
Adaptive behaviour	0.152	0.371	−0.288	*0.454 (0.009)**	0.229	−0.349 (0.050)	*− 0.334 (0.038)**	*0.368 (0.021)**
HC at a CA of 18 months	− 0.092	0.031	− 0.002	0.177	–	− 0.174	− 0.167	*0.740 (< 0.001)**

Day 0: the day of inflammatory symptom onset
The values are Pearson correlation coefficient. If the p-value is less than 0.05, with (p-value)
All values are adjusted for gestational age and postmenstrual age of inflammatory event
^aSeizure (1: yes, 2: no), ^bVoltage based classification (1: normal, 2: moderate abnormal, 3: severe abnormal), ^¶Brain WMI (1: normal, 2: mild, 3: moderate to severe)
aEEG amplitude-integrated EEG; PMA Postmenstrual age; WMI White matter injury; HC Head circumference
* p < 0.05

ISSN: 1471-2431