Factors associated with neurodevelopment in preterm infants with systematic inflammation

BMC Pediatrics

Table 3 Correlation between Biomarkers (Day 0) and Neurologic Findings during NICU Admission in the Inflammation Group

	I/T ratio	let	CRP	IL-1 beta		IL-8		TNF alpha		S100B		Enolase2		MBP
	I/T ratio	let	CRP	C	P	C	P	C	P	C	P	C	P	C	P
aEEG: Day 0
Maturation score	*−0.496 (0.026)**	0.048	0.037	*−0.662 (0.019)**	0.055	− 0.264	0.063	0.240	−0.169	− 0.130	0.115	− 0.247	0.224	− 0.101	0.018
Seizure^a	*−0.584 (0.007)**	−0.086	0.080	*−0.858 (0.001)**	0.215	0.092	0.015	0.220	−0.405	0.253	0.056	0.208	0.199	0.042	*−0.566 (0.044)**
Voltage based^b	0.401 (0.052)	−0.094	−0.092	*0.608 (0.036)**	0.281	0.138	0.744	−0.173	0.147	−0.019	0.183	0.049	−0.148	0.049	−0.012
aEEG: PMA 35 weeks
Maturation score	−0.621 (0.055)	0.314	−0.208	−0.278	− 0.109	0.046	− 0.280	−0.338	− 0.252	−0.013	0.321	−0.012	0.075	−0.056	− 0.148
Seizure^a	0.172	−0.376	−0.597	0.312	1.000	0.219	−0.417	0.256	0.179	−0.053	0.179	0.116	−0.030	0.219	0.362
Voltage based^b	0.085	− 0.295	0.359	0.021	0.030	0.037	−0.253	0.391	0.474	0.200	0.310	0.146	0.249	0.174	0.425
HC: 36 weeks (cm)	0.048	0.283	−0.1	0.010	− 0.405	*− 0.742 (0.014)**	0.408	*− 0.771 (0.009)**	− 0.493	*− 0.792 (0.006)**	0.174	*− 0.729 (0.017)**	*− 0.725 (0.018)**	− 0.286	− 0.405
Brain WMI at discharge^c	*0.483 (0.031)**	− 0.027	− 0.098	0.426	−0.185	− 0.104	0.128	− 0.073	−0.195	− 0.278	− 0.374	− 0.303	−0.007	− 0.122	0.077

Day 0: the day of inflammatory symptom onset
The values are Pearson correlation coefficient. If the p-value is less than 0.05, with (p-value). All values are adjusted for gestational age and postmenstrual age of inflammatory event
^aSeizure (1: yes, 2: no), ^bVoltage based classification (1: normal, 2: moderate abnormal, 3: severe abnormal), ^cBrain WMI (1: normal, 2: mild, 3: moderate to severe)
C Cerebrospinal fluid; P plasma; MBP Myelin Basic Protein; TNF alpha Tumor Necrosis Factor-alpha; aEEG Amplitude-integrated electroencephalography; PMA postmenstrual age; HC head circumference; WMI white matter injury
* p < 0.05

ISSN: 1471-2431