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Table 2 Short-term Neurological and CA of 18 months Neurodevelopmental Outcome

From: Factors associated with neurodevelopment in preterm infants with systematic inflammation

 

Control (n = 49)

I (n = 45)

P-value†

P-value§

HC at PMA 36 weeks (z-score)

−1.45 (−3.92, 0.51)

−2.12 (−5.28, 0.17)

< 0.001*

0.049*

aEEG at PMA 35 weeks

 

 Maturation score

9.50 (4, 13)

8 (4, 12)

0.002*

0.017*

WMI on MRI at discharge

  

0.008*

0.036*

 None

48 (98)

33 (73.3)

  

 Mild

1 (2)

8 (17.8)

  

 Moderate to severe

0 (0)

4 (8.9)

  

HC at a CA of 18 months (z-score)

0.32 (−2.42, 2.36)

− 0.88 (−3.91, 2.13)

< 0.001*

0.005*

Bayley-III and Cerebral palsy at a CA of 18 months

 Cognitive

95 (85, 125)

90 (55, 120)

0.006*

0.076

 Language

97 (74, 121)

89 (50, 121)

0.015*

0.108

 Motor

100 (82, 118)

91 (46, 110)

0.002*

0.029*

 Social Emotional

95 (80, 110)

90 (55, 115)

0.066

0.311

 Adaptive Behaviour

92 (61, 115)

84 (48, 111)

0.005*

0.055

 Cerebral palsy

2 (4.0)

6 (13.3)

0.080

0.240

  1. Values are presented as average (min, max), or number (%)
  2. †P-values are adjusted for gestational age
  3. §P-values are adjusted for gestational age, Apgar score, RDS, BPD, PDA operation, ROP (≥stage III), and IVH (≥Grade III)
  4. HC head circumference; aEEG amplitude-integrated EEG; PMA Postmenstrual age; WMI White matter injury; MRI magnetic resonance imaging; CA corrected age, Bayley-III Bayley Scales of Infant and Toddler Development III
  5. * p < 0.05
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BMC Pediatrics

ISSN: 1471-2431

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