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Table 1 Perinatal Characteristics, Neonatal Morbidities and Laboratory Result

From: Factors associated with neurodevelopment in preterm infants with systematic inflammation

 

Control (n = 49)

I (n = 45)

P-value

Gestational age (week)

29+ 2 (24+ 1, 34+ 2)

26+ 6 (24+ 0, 33+ 1)

< 0.001*

Birth weight (g)

1090 (540, 1340)

770 (420, 1400)

< 0.001*

Birth HC (z-score)

−0.49 (− 3.28, 2.55)

− 0.61 (−4.26, 0.98)

0.255

Male

20 (40.8)

28 (62.2)

0.100

Multiple birth

21 (42.9)

20 (44.4)

0.877

Apgar score

 At 1 min

5 (1, 8)

3 (0, 8)

0.028*

 At 5 min

7 (1, 9)

7 (0, 9)

0.004*

Cesarean section

33 (67.3)

28 (62.2)

0.440

PROM

10 (20.4)

7 (15.6)

0.541

HCA

19 (38.8)

21 (46.7)

0.440

Preeclampsia

2 (4.1)

3 (6.7)

0.577

Antenatal steroid

42 (85.7)

41 (91.1)

0.294

SGA

14 (28.6)

15 (33.3)

0.618

RDS

26 (53.1)

35 (77.8)

0.012*

Moderate to severe BPD

11 (22.4)

30 (66.7)

< 0.001*

PDA operation

2 (4.1)

14 (31.1)

< 0.001*

ROP ≥ stage III

2 (4.1)

15 (33.3)

< 0.001*

IVH, grade III

0 (0.0)

2 (4.4)

0.136

Culture Proven Sepsis

0 (0.0)

11 (24.4)

< 0.001*

NEC ≥ stage II

0 (0.0)

2 (4.44)

< 0.001*

The number of Inflammatory episode

 

1 (1, 6)

–

Postnatal days of Inflammatory episode

 

17 (0, 85)

–

WBC (×103/μl)

–

11.44 (1.00, 39.00)

–

I/T ratio

–

0.00 (0.00, 0.89)

–

Platelet (×103/μl)

–

157 (30, 811)

–

CRP (mg/dL)

–

1.96 (0.01, 18.21)

–

  1. Values are presented as median (min, max), or number (%)
  2. HC head circumference; PROM premature rupture of membranes; HCA histologic chorioamnionitis; SGA small for gestational age; RDS respiratory distress syndrome; BPD bronchopulmonary dysplasia; PDA patent ductus arteriosus; ROP retinopathy of prematurity; IVH intraventricular hemorrhage; I/T ratio immature to total neutrophil ratio; CRP C-reactive protein
  3. * p < 0.05