Study protocol: a multicenter, uncontrolled, open-label study of palivizumab in neonates, infants, and preschool children at high risk of severe respiratory syncytial virus infection

Table 1 Mechanisms of severe respiratory syncytial virus (RSV) infection in the rare diseases targeted in this study

Disease group	Mechanism for severe RSV infection
Disease group	Reduced ventilation competence^a	Difficulty in expectoration^b
Pulmonary hypoplasia		○
Airway stenosis	○	○
Congenital esophageal atresia	Δ	○
Inherited metabolic disease	○
Neuromuscular disease		○

○ = Yes, Δ = Yes, depending on the condition, Blank = not applicable
^aReduced ventilation competence: Because of their reduced ventilation competence, children with airway stenosis who develop RSV-induced lower respiratory tract infection may experience hypoxia
^bDifficulty in expectoration: Because of the difficulty in expectoration, patients cannot eliminate RSV via the sputum, which results in prolonged infection. Secretions retaining in the respiratory tract make ventilation difficult

ISSN: 1471-2431