Genetic variants and physical activity interact to affect bone density in Hispanic children

BMC Pediatrics

Table 1 Polygenic Risk Score Compositions^{1, 2}

Marker	Gene	Risk Allele (Freq)	Chr	Position
TBBMD PRS
rs452369	SLC8A1	A(0.24)	2	40,157,593
rs529125	SUPT3H	A(0.87)	6	44,829,351
rs2800718	LOC105377989	A(0.21)	6	127,079,180
rs10953178	SEM1	G(0.36)	7	96,501,326
rs950083		C(0.74)	10	122,717,980
rs12273330	DGKZ	A(0.03)	11	46,340,356
rs4394609		A(0.93)	1	22,406,025
rs914153		A(0.70)	21	38,980,535
rs370055571	MAP 4 K3	A(0.01)	2	39,258,582
LBBMD PRS
rs9846561	LEKR1	A(0.96)	3	157,040,993
rs16934799	KCNMA1	A(0.98)	10	77,448,298
rs2087058	LOC105369777	G(0.54)	12	54,199,621
rs1286083	RPS6KA5	G(0.12)	14	90,976,435
rs7071206		A(0.75)	10	77,641,558
rs6684375		G(0.90)	1	22,379,941

¹ Polygenic Risk Score includes SNPs that are statistically significant or nominally significant associated with BMD in Viva La Familia Study
² BMD bone mineral density, DGKZ Diacylglycerol Kinase Zeta, PRS Polygenic Risk Score, KCNMA1 Potassium Calcium-Activated Channel Subfamily M Alpha 1, LEKR1 Leucine, Glutamate and Lysine Rick 1, MAP 4K3 Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3, RPS6KA5 Ribosomal Protein S6 Kinase A5, SEM1 26S Proteasome Complex Subunit, SLC8A1 Solute Carrier Family 8, SUPT3H SPT3 Homolog, SAGA and STAGA Complex Component

ISSN: 1471-2431