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Table 1 Characteristics of neonates treated with combination therapy (Moxifloxacin and another antibiotic) for Mycoplasma Hominis CNS infection

From: Mycoplasma hominis meningitis in an extremely preterm newborn: a case report

  Gestational Age Age at presentation Clinical presentation Confirmation of diagnosis Empirical antibiotic therapy and duration Antibiotics for Mycoplasma Hominis Outcome
Hata and colleagues3 38 weeks 25 days Fever, vomiting, focal seizures 16S RNA PCR Ampicillin & Cefotaxime (day 1–2) Ciprofloxacin (day 6–17) Acyclovir (day 6–8) Chloramphenicol (day 8–17) Minocycline for 28 days (day 6–34) Moxifloxacin for 17 days (day 17–34) Recovery with left hemiplegia
Watt and colleagues5 26 weeks 7 days Apnea, hypotonia, generalized seizures 16S RNA PCR Ampicillin and Gentamycin (day1-8) Ceftazidime (day 1–5 ) Vancomycin (day 8–19 ) Acyclovir (day 8–19) Meropenem (day 12–19 ) Doxycycline for 6 weeks (day 19–60) Moxifloxacin for 6 weeks (day 19–60) Recovery, neurological outcomes not reported
Our case 25 + 6 weeks 7 days Lethargy, tachycardia, generalized seizures 16S RNA PCR Ampicillin and Gentamycin (day 1–2) Azithromycin (day 3–6) Vancomycin and cefotaxime (day 7–10) Doxycycline for 6 weeks (day 10–52) Moxifloxacin for 6 weeks (day 10–52) Recovery with normal neurological examination at discharge, follow up at 6 months showed normal neurological examination