Skip to main content

Table 3 The effect of valproic acid on bone metabolism in epileptic children

From: Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies

Author

Bone metabolism index (Mean ± standard deviation)

Serum calcium (mg/dL)

Serum phosphorus (mg/dL)

Alkaline phosphatase (U/L)

Parathyroid hormone (pg/mL)

Osteocalcin (Inconsistent)d

25-hydroxy-vitamin D (ng/ml)

Valproic acid

Control

Valproic acid

Control

Valproic acid

Control

Valproic acid

Control

Valproic

acid

Control

Valproic acid

Control

Akin R [11]

9.08 ± 0.1

9.42 ± 0.1

5.39 ± 0.2

5.24 ± 0.2

194 ± 18c

204 ± 11c

Kafali G [17]

569.35 ± 263.35

303.7 ± 109.8

 

Erbayat Altay E [14]

Voudris K [23]

162.3 ± 71.8

144.9 ± 53.3

Caksen H [15]

9.84 ± 0.62

9.80 ± 0.39

5.02 ± 0.72

5.10 ± 0.58

481.51 ± 165.56

554.77 ± 210.41

35.38 ± 31.06

33.14 ± 17.18

3.13 ± 3.22

3.11 ± 2.43

Oner N [19]

10.02 ± 0.4a

10.42 ± 0.4a

4.87 ± 0.8

5.1 ± 1.1

276.3 ± 136.6

201.4 ± 82.9

Kumandas S [18]

9.9 ± 0.3

9.7 ± 0.4

4.4 ± 0.5

4.5 ± 0.4

561 ± 166

487 ± 82

39.1 ± 12.8

36.3 ± 4.9

15.1 ± 3.5e

16.6 ± 4.7e

Babayigit A [13]

9.95 ± 0.41

9.89 ± 0.35

3.53 ± 0.57

3.49 ± 0.47

506.3 ± 215.1

436.5 ± 147.9

43.46 ± 22.1

38.17 ± 14.8

17.87 ± 7.27

22.3 ± 7.1

Rauchenzauner M [21]

9.89 ± 0.32a

9.37 ± 0.3a

4.2 ± 0.6b

4.5 ± 0.6b

43.2 ± 25.6

49.9 ± 33.8

Aksoy A [12]

9.84 ± 0.38

9.93 ± 0.45

4.87 ± 0.44

4.90 ± 0.44

422.74 ± 177.52

518.34 ± 158.82

100.27 ± 34.09

120.93 ± 41.57

37.68 ± 30.73

38.82 ± 27.33

Yaghini O [20]

9.67 ± 0.37

9.58 ± 0.46

4.78 ± 0.75

4.84 ± 0.36

204.10 ± 58

270.13 ± 106

54.82 ± 16.33

80.09 ± 49.35

Serin HM [22]

9.42 ± 0.44

9.5 ± 0.2

4.9 ± 0.5

4.8 ± 0.8

202.36 ± 65.87

183.7 ± 50.9

44.29 ± 20.04

35.1 ± 13

Hasaneen B [7]

7.9 ± 1.2

8.6 ± 1.2

4.5 ± 0.8

5.3 ± 0.7

38.1 ± 27.2

29.6 ± 7.4

  1. aData has been converted, Ca2+: mmol/L × 4.008 = mg/dL; bData has been converted, P: mmol/L × 3.097 = mg/dL; cData has been converted, mU/ml ×  1000/1000 = U/L; dDifferent detection methods cannot be used to achieve unity; eData has been converted, ug/L× 1000/1000 = ng/ml