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Table 3 Factors of gastrointestinal perforation in 6-month tracking stratified by variables listed in the table by using Cox regression

From: The incidence of collagen-associated adverse events in pediatric population with the use of fluoroquinolones: a nationwide cohort study in Taiwan

Fluoroquinolones

With

Without

Ratio

With vs. Without

Stratified

Events

PDs

Rate (per 105 PDs)

Events

PDs

Rate (per 105 PDs)

Adjusted HR

95% CI

95% CI

P

Total

17

5,940,776.06

0.29

68

23,707,602.75

0.29

0.998

1.330

0.778

2.276

0.255

Gender

 Male

10

3,060,435.00

0.33

31

12,297,000.62

0.25

1.296

1.744

0.921

2.983

0.643

 Female

7

2,880,341.06

0.24

37

11,410,602.12

0.32

0.749

1.008

0.556

1.724

0.297

Age group (years)

 < 1

1

183,600.00

0.54

4

820,422.12

0.49

1.117

1.503

0.876

2.572

0.675

 1

2

256,265.94

0.78

3

876,927.19

0.34

2.281

2.279

0.998

4.027

0.052

 2

1

286,506.19

0.35

4

1,024,530.50

0.39

0.894

1.194

0.702

1.960

0.536

 3

2

325,930.75

0.61

5

1,282,879.44

0.39

1.574

1.822

0.943

2.894

0.071

 4

1

384,465.19

0.26

6

1,542,322.12

0.39

0.669

0.899

0.525

1.275

0.489

 5–9

3

1,677,499.81

0.18

14

6,622,008.94

0.21

0.846

1.139

0.669

1.949

0.376

 10–14

2

1,521,852.94

0.13

10

6,123,547.69

0.16

0.805

1.080

0.635

1.851

0.447

15

5

1,304,655.25

0.38

22

5,414,964.75

0.41

0.943

1.271

0.742

2.170

0.285

Catastrophic illness

 Without

16

5,907,063.87

0.27

68

23,616,531.12

0.29

0.941

1.264

0.735

2.163

0.194

 With

1

33,712.19

2.97

0

91,071.62

0.00

0.796

Low-income household

 Without

16

5,789,090.44

0.28

68

23,320,517.25

0.29

0.948

1.277

0.744

2.183

0.182

 With

1

151,685.62

0.66

0

387,085.50

0.00

0.785

Season

 Spring

5

1,209,564.81

0.41

23

6,731,139.19

0.34

1.210

1.628

0.952

2.792

0.073

 Summer

3

1,211,624.37

0.25

12

5,549,493.38

0.22

1.145

1.539

0.901

2.639

0.102

 Autumn

2

1,596,290.69

0.13

10

5,377,612.87

0.19

0.674

0.907

0.524

1.551

0.773

 Winter

7

1,923,296.19

0.36

23

6,049,357.31

0.38

0.957

1.288

0.751

2.204

0.288

Urbanization level

 1 (the highest)

6

1,305,977.19

0.46

30

6,700,633.87

0.45

1.026

1.378

0.808

2.364

0.134

 2

2

2,119,226.31

0.09

12

8,911,079.56

0.13

0.701

0.942

0.553

1.616

0.446

 3

7

1,142,905.31

0.61

19

3,835,392.81

0.50

1.236

1.663

0.971

2.843

0.059

 4 (the lowest)

2

1,372,667.25

0.15

7

4,260,496.50

0.16

0.887

1.185

0.692

2.041

0.334

Level of care

 Hospital center

6

222,455.87

2.70

26

1,083,958.87

2.40

1.124

1.156

0.884

2.588

0.240

 Regional hospital

5

343,936.38

1.45

19

1,737,590.94

1.09

1.329

1.794

0.972

3.059

0.062

 Local hospital

4

281,046.94

1.42

15

1,249,182.12

1.20

1.185

1.589

0.932

2.735

0.179

 Physician clinics

2

5,093,336.87

0.04

8

19,636,870.81

0.04

0.964

1.290

0.759

2.214

0.304

  1. PDs Person-days, Adjusted HR Adjusted Hazard ratio: Adjusted for the variables listed in Table 2, CI Confidence interval