Survival and ocular preservation in a long-term cohort of Japanese patients with retinoblastoma

BMC Pediatrics

Table 3 Characteristics, treatment and secondary neoplasms of deceased patients

Pt	Sex	Age at diagnosis, death		Observation period	Onset	Invasion^a	Treatment for retinoblastoma RT /Initial sys-chemo/Enucl				Family history	Secondary malignancy	Causes of death	Onset
1	male	21 m,	37 m	15 m	bilateral	CNS (tri.)	yes^b	no		Lt	NR	no	trilateral disease	1987
2	male	17 m,	37 m	18 m	trilateral	CNS (tri.)	yes ^b	yes		no	no	no	trilateral disease	2014
3	male	0 m,	24 m	23 m	bilateral	CNS (tri.)	yes	no		Rt	NR	no	trilateral disease	1989
4	male	21 m,	49 m	27 m	unilateral	systemic	yes ^b	no		Lt	no	no	systemic disease	1985
5	female	1 m,	93 m	92 m	bilateral	CNS (meta.)	yes	no	Pr →	Rt	yes	no	CNS metastasis	1990
6	male	7 m,	298 m	290 m	bilateral	CR → 2nd	yes	no		Lt	no	Os	secondary Os	1991

^a Invasion means the sites affected during the advanced disease course
^b External beam radiotherapy for metastasis
m months; meta metastasis; tri trilateral; Lt left; Rt right; Pr preservation; NR not recorded; RB retinoblastoma; CR complete remission; Os osteosarcoma; RT external beam radiotherapy

ISSN: 1471-2431