C-reactive protein- and clinical symptoms-guided strategy in term neonates with early-onset sepsis reduced antibiotic use and hospital stay: a quality improvement initiative

Table 5 Antibiotic therapy and length of hospital stay in patients with early-onset sepsis

	Pre-implementation Period 1 (n = 61)	Post-implementation Period 2 (n = 59)	P-value
AB-days	7 (7–8)	5 (5–6)	P < 0.001
IV-days	5 (5–7)	3 (3–4)	P < 0.001
Oral-days	0 (0–4)	2 (2–3)	P = 0.064
H-days	7 (6–8)	5 (4–6)	P < 0.001

Term infants treated for early-onset sepsis (EOS) pre- and post-implementation of new antibiotic treatment guidelines. Period 1 and 2 include term infants with culture-negative sepsis who met the criteria of the guidelines. Data are median (IQR). AB-days days with antibiotic treatment, IV-days days with intravenous antibiotic treatment, Oral-days days with oral solution antibiotic treatment, H-days Hospital stay in days

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