Characteristic | Infants receiving at least 1 dose of palivizumab N = 271 | Infants receiving no palivizumab N = 24,058 | Univariable | Multivariable | ||||
---|---|---|---|---|---|---|---|---|
n | (%) | n | (%) | OR | (95% CI) | aOR | (95% CI) | |
Sex | ||||||||
Males | 157 | (57.9) | 13,280 | (55.2) | Ref | Ref | ||
Females | 114 | (42.1) | 10,776 | (44.8) | 0.9 | (0.7–1.1) | – | – |
Year of birth | ||||||||
2002–2009 | 52 | (19.2) | 14,844 | (61.7) | Ref | Ref | ||
2010–2013 | 219 | (80.8) | 9214 | (38.3) | 6.8 | (5.0–9.2) | 8.8 | (6.1–12.6) |
Indigenous status | ||||||||
Non-Aboriginal | 238 | (87.8) | 21,086 | (87.6) | Ref | Ref | ||
Aboriginal | 33 | (12.2) | 2972 | (12.4) | 1.0 | (0.7–1.4) | 0.8 | (0.4–1.4) |
Gestational age | ||||||||
< 28 weeks | 208 | (76.8) | 1007 | (4.2) | 66.4 | (46.2–95.6) | 7.4 | (1.8–30.9) |
28–32 weeks | 15 | (5.5) | 3688 | (15.3) | 1.3 | (0.7–2.4) | 0.5 | (0.1–1.9) |
33–36 weeks | 13 | (4.8) | 8107 | (33.7) | 0.5 | (0.3–1.0) | 0.5 | (0.2–1.2) |
≥ 37 weeks | 35 | (12.9) | 11,256 | (46.8) | Ref | Ref | ||
Birth weight | ||||||||
< 1500 g | 221 | (81.5) | 2926 | (12.2) | 22.3 | (13.0–38.3) | 1.5 | (0.4–6.3) |
1500–2499 g | 14 | (5.2) | 7786 | (32.4) | 0.5 | (0.3–1.1) | 0.9 | (0.4–2.1) |
2500–2999 g | 14 | (5.2) | 4132 | (17.2) | Ref | Ref | ||
3000–3499 g | 13 | (4.8) | 4341 | (18.0) | 0.9 | (0.4–1.9) | 0.6 | (0.3–1.4) |
≥ 3500 g | 9 | (3.3) | 4873 | (20.3) | 0.6 | (0.2–1.3) | 0.4 | (0.2–1.0) |
Geographical area of birth | ||||||||
Metropolitan | 196 | (72.3) | 19,010 | (79.0) | Ref | Ref | ||
Rural | 55 | (20.3) | 3262 | (13.6) | 1.6 | (1.2–2.2) | 1.6 | (1.0–2.5) |
Remote | 19 | (7.0) | 1701 | (7.1) | 1.1 | (0.7–1.7) | 0.9 | (0.4–1.9) |
Major congenital anomalies | ||||||||
No | 145 | (53.5) | 22,061 | (91.7) | Ref | Ref | ||
Yes | 126 | (46.5) | 1997 | (8.3) | 9.6 | (7.5–12.2) | 3.8 | (2.7–5.4) |
Congenital heart disease | ||||||||
No | 45 | (16.6) | 21,709 | (90.2) | Ref | Ref | ||
Yes | 226 | (83.4) | 2259 | (9.4) | 48.3 | (35.0–66.7) | 5.8 | (3.8–8.9) |
Chronic lung disease | ||||||||
No | 79 | (29.2) | 23,111 | (96.1) | Ref | Ref | ||
Yes | 192 | (70.8) | 947 | (3.9) | 59.3 | (45.3–77.7) | 2.8 | (1.8–4.5) |
Season of birth | ||||||||
Spring | 38 | (14.0) | 5918 | (24.6) | Ref | Ref | ||
Summer | 43 | (15.9) | 6005 | (25.0) | 1.1 | (0.7–1.7) | 1.1 | (0.6–1.9) |
Autumn | 104 | (38.4) | 6170 | (25.6) | 2.6 | (1.8–3.8) | 4.2 | (2.6–6.7) |
Winter | 86 | (31.7) | 5965 | (24.8) | 2.3 | (1.5–3.3) | 3.4 | (2.1–5.6) |
Multiple birth | ||||||||
Singleton | 221 | (81.5) | 20,527 | (85.3) | Ref | Ref | ||
Multiple | 50 | (18.5) | 3495 | (14.5) | 1.3 | (1.0–1.8) | 0.6 | (0.4–0.9) |
Number of previous pregnancies | ||||||||
0 | 90 | (33.2) | 7595 | (31.6) | Ref | Ref | ||
1 | 70 | (25.8) | 6272 | (26.1) | 0.9 | (0.7–1.3) | 1.3 | (0.9–1.9) |
2 | 33 | (12.2) | 4044 | (16.8) | 0.7 | (0.5–1.0) | 1.1 | (0.7–1.9) |
≥ 3 | 78 | (28.8) | 6111 | (25.4) | 1.1 | (0.8–1.5) | 1.4 | (0.9–2.1) |
Socioeconomic status | ||||||||
0–10% (most dis) | 42 | (15.5) | 2967 | (12.3) | Ref | Ref | ||
10–25% | 38 | (14.0) | 4628 | (19.2) | 0.6 | (0.4–0.9) | 0.6 | (0.4–1.1) |
25–75% | 134 | (49.4) | 10,688 | (44.4) | 0.9 | (0.6–1.3) | 0.8 | (0.5–1.2) |
75–90% | 28 | (10.3) | 2780 | (11.6) | 0.7 | (0.4–1.2) | 0.8 | (0.5–1.6) |
90–100% | 12 | (4.4) | 1213 | (5.0) | 0.7 | (0.4–1.3) | 0.7 | (0.3–1.5) |
Mother smoking during pregnancy | ||||||||
No | 224 | (82.7) | 18,861 | (78.4) | Ref | Ref | ||
Yes | 47 | (17.3) | 5161 | (21.5) | 0.8 | (0.6–1.1) | 1.0 | (0.6–1.5) |