Skip to main content

Table 3 Genotypic and allelic distribution of APLN T-1860C and APLNR G212A polymorphisms in non-obese and obese children

From: Relationships of apelin concentration and APLN T-1860C polymorphism with obesity in Thai children

APLN T-1860C Obese
n (%)
Non-obese
n (%)
Genotypic or allelic
P-value
Total: genotype
 CC 52 (26.3) 25 (19.7)  
 CT 41 (20.7) 25 (19.7) 0.325
 TT 105 (53.0) 77 (60.6)  
 TT vs CT + CCa 1.36 (0.87–2.15)   
[0.170]   
 C allele 145 (0.366) 75 (0.295) 0.062
 T allele 251 (0.634) 179 (0.705)  
Female: genotype
 CC 17 (18.7) 5 (7.7)  
 CT 41 (45.0) 25 (38.5) 0.042*
 TT 33 (36.3) 35 (53.8)  
 TT vs CT + CCa 2.05 (1.08–3.92)
[0.029]*
Reference  
 C allele 75 (0.412) 35 (0.269) 0.009**
 T allele 107 (0.588) 95 (0.731)  
Male: genotype
 CC -b -b  
 CT - b - b  
 TT - b - b  
 T vs Ca 1.02 (0.52–2.00)
[0.902]
Reference  
 C allele 70 (0.327) 40 (0.323) 0.931
 T allele 144 (0.673) 84 (0.677)  
APLNR G212A Obese
n (%)
Non-obese
n (%)
Genotypic or allelic
P-value
Total: genotype
 AA 3 (1.5) 4 (3.2) 0.121
 AG 52 (26.3) 22 (17.3)  
 GG 143 (72.2) 101 (79.5)  
 GG vs AA+AGa 1.49 (0.88–2.54) Reference  
[0.137]  
 A allele 58 (0.146) 30 (0.118) 0.303
 G allele 338 (0.854) 224 (0.882)  
Female: genotype
 AA 1 (1.1) 2 (3.1) 0.297
 AG 22 (24.2) 10 (15.4)  
 GG 68 (74.7) 53 (81.5)  
 GG vs AA+AGa 1.49 (0.68–3.28)
[0.310]
Reference  
 A allele 24 (0.132) 14 (0.108) 0.432
 G allele 158 (0.868) 116 (0.892)  
Male: genotype
 AA 2 (1.9) 2 (3.2)  
 AG 30 (28.0) 12 (19.4) 0.410
 GG 75 (70.1) 48 (77.4)  
 GG vs AA+AGa 1.43 (0.70–2.96)
[0.330]
Reference  
 A allele 34 (0.159) 16 (0.129) 0.456
 G allele 180 (0.841) 108 (0.871)  
  1. aValues are the odds ratio with 95% confidence interval in parentheses; P − values in brackets
  2. bSince the apelin gene is on the X chromosome (only one copy), it is irrelevant to present the genotype data for males
  3. Significance levels: * P < 0.05; ** P < 0.01 based on the results of a chi-squared test