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Table 3 The intussusception cases and case ratios during post-rotavirus vaccine introduction period compared to pre-introduction periods

From: Prospective surveillance for intussusception in Indian children aged under two years at nineteen tertiary care hospitals

 

Post-RVV period

(Apr- Sep 2017)

Pre-RVV period

(Oct 2016 - Mar 2017)

Pre-RVV period

(Apr- Sep 2016)

Region (number of sites)a

No of cases

IS case rate

No of cases

IS case ratio

RR (95% CI) for cases

RR (95% CI) for IS case rate

No of cases

IS ratio

RR (95% CI) for cases

RR (95% CI) for IS case rate

East (n = 2)a

20

20.4

29

29.9

0.69 (0.33–1.2)

0.67 (0.3–1.28)

45

34.6

0.44 (0.2–1.15)

0.58 (0.32–1.2)

North (n = 1)a

0

0

2

27.4

–

–

3

37.5

–

–

South (n = 1)a

6

13.3

8

20.4

0.75 (0.45–1.24)

0.65 (0.48–1.23)

11

26.4

0.55 (0.28–1.2)

0.51 (0.3–1.22)

Pooled (n = 4)a

26

16.3

39

27.2

0.67 (0.34–1.19)

0.6 (0.3–1.18)

59

32.8

0.44 (0.22–1.18)

0.5 (0.3–1.2)

  1. Note: IS Intussusception, Intussusception (IS) case rate Intussusception cases per 1000 paediatric surgery admission, RVV Rotavirus vaccine, RR risk ratio with 95% confidence interval (CI), RVV: Rotavirus vaccine
  2. The comparison includes the data from four study sites in three states
  3. aNumbers in the bracket with the regions indicate the numbers of study sites per region where RVV was introduced
  4. Post-RVV period: April 2017 to September 2017 (6 months)
  5. Pre-RVV period: Comparison has been done for two pre-intervention periods of 6 months each; October 2016 to March 2017- the immediate pre-RVV introduction period and April 2016 to September 2016- the calendar months comparable period during the previous year