The efficacy and safety of peripheral intravenous parenteral nutrition vs 10% glucose in preterm infants born 30 to 33 weeks’ gestation: a randomised controlled trial

Table 2 Growth outcomes

Outcome	P-PN (n = 42)	Control (n = 50)	Adjusted mean difference (95% CI)	Adjusted P value^a
Weight gain from birth to day 21, g/d	18.7 (6.6)	14.8 (6.0)	3.9 (1.3 to 6.6)	0.004
Per protocol weight gain from birth to day 21, g/d^b	19.3 (6.3)	14.8 (6.1)	4.4 (1.9 to 7.0)	0.0008
Birthweight regained, d, (n = 41/49)	9.8 (2.9)	12.3 (2.8)	0.8 (0.7 to 0.9)^c	< 0.0001
Weight gain from birth to discharge home, g/d, (n = 42/49)	24.1 (5.3)	19.4 (8.4)	4.9 (2.0 to 7.8)	0.001
Length gain from birth to discharge home, mm/d, (n = 39/48)	1.2 (0.5)	1.0 (0.7)	0.3 (0.0 to 0.5)	0.02
Head circumference gain from birth to discharge home, mm/d, (n = 39/47)	0.9 (0.4)	0.9 (0.4)	0.1 (−0.1 to 0.2)	0.4
Weight at day 21, g^d	2087 (332)	2042 (340)	76 (24 to 129)	0.004
Length at day 21 ± 2 days, cm, (n = 28/34)^d	44.5 (2.8)	43.4 (2.1)	1.3 (0.5 to 2.1)	0.001
Head circumference at day 21 ± 2 days, cm, (n = 28/34)^d	31.0 (2.0)	31.0 (1.4)	0.2 (−0.3 to 0.6)	0.5
Weight on discharge home, g, (n = 42/49)^d	2561 (328)	2463 (359)	129 (4 to 254)	0.05
Length on discharge home, cm, (n = 39/48)^d	45.8 (2.3)	45.3 (2.2)	0.7 (0.2 to 1.5)	0.1
Head circumference on discharge home, cm, (n = 39/47)^d	32.8 (1.2)	32.8 (1.7)	0.1 (0.5 to 0.7)	0.7

Data are presented as mean (SD)
^a Adjusted for sex and gestational age 30^+ 0 to 31^+ 6 and 32^+ 0 to 33^+ 6 weeks
^b Per protocol analysis included infants whose clinical care adhered to the study protocol, i.e. received P-PN and Control via peripheral line: P-PN n = 39, Control n = 49
^c Adjusted ratio of means
^d Additionally adjusted for corresponding anthropometric measure at birth

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