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Table 3 Functional immune parameters in neonates and paired older siblings with hand, foot, and mouth disease

From: Neonatal hand, foot, and mouth disease due to coxsackievirus A6 in Shanghai

Parameter Neonates with HFMD Neonate controls P-value1 Older siblings with HFMD Older sibling controls P-value2 P-value3
CD3 T-cell 2837.2 (2243.3, 3982.1) 3536.3 (3196.6, 4450.2) 0.01 2212.1 (1932.2, 2918.3) 2704.5 (2040.0, 3452.0) 0.03 0.01
CD4 T-cell 2161.6 (1845.8, 4132.7) 2488.5 (2165.5, 3379.0) 0.48 1224.5 (1074.4, 2743.7) 1373 (1041.0, 1804.0) 0.12 0.01
CD8 T-cell 534.0 (314.2, 824.6) 970.0 (904.5, 1150.5) <  0.01* 911.7 (534.8, 1843.2) 1243.5 (998.0, 1531.0) 0.27 0.02
CD16 + CD56+ (NK cell) 250.3 (123.9, 325.4) 361.0 (239.5, 478.5) 0.72 573.9 (342.7, 1267.3) 379.5 (224.0, 1091.0) 0.02 0.79
IgG 3.2 (2.3, 4.1) 6.2 (5.2, 7.0) 0.68 9.7 (6.4, 11.6) 9.5 (8.9, 10.6) 0.12 0.09
IgA <  0.3 <  0.3 1 2.0 (1.0, 2.6) 1.2 (0.9, 1.5) <  0.01* <  0.01*
IgM 0.4 (0.2, 0.6) 0.2 (0.2, 0.3) <  0.01*c 2.5 (1.2, 3.2) 1.1 (0.6, 1.2) 0.05 <  0.01*
IL-1β 730.1 (384.8, 937.5) 61.9 (22.5, 71.5) <  0.01*c 1019.3 (776.2, 1832.9) 88.8 (56.5, 138.2) <  0.01*c <  0.01*c
IL-2R 1516.4 (497.3, 2732.3) 1438.5 (1277.5, 1556.5) <  0.01*c 1392.9 (476.8, 1732.2) 485.0 (394.0, 669.1) <  0.01*c 0.03c
IL-6 32.4 (28.2, 67.3) 3.8 (3.1, 48.4) <  0.01*c 16.9 (14.3, 80.9) 5.2 (2.8, 14.9) <  0.01*c 0.61c
IL-8 63.6 (14.6, 1283.6) 110.8 (19.7, 1866.0) <  0.01*c 58.2 (20.8, 1282.6) 20.1 (7.7, 321.0) <  0.01*c 0.91c
IL-10 26.4 (14.2, 46.8) 17.5 (12.3, 53.1) 0.01c 79.3 (41.4, 135.4) 2.5 (1.3, 32.5) <  0.01*c <  0.01*c
TNF-α 15.3 (9.5, 38.2) 13.2 (11.0, 26.7) <  0.01*c 18.6 (11.6, 33.3) 11.2 (8.9, 17.3) <  0.01*c 0.41c
  1. P-value1T-test for the comparison between neonatal HFMD and age-matched controls, P-value2T-test for the comparison between older siblings with HFMD and age-matched controls, P-value3T-test for the comparison between neonatal and older sibling HFMD cases
  2. *Statistical significance
  3. cT-test after log transformation