Table 3 Functional immune parameters in neonates and paired older siblings with hand, foot, and mouth disease
From: Neonatal hand, foot, and mouth disease due to coxsackievirus A6 in Shanghai
Parameter | Neonates with HFMD | Neonate controls | P-value1 | Older siblings with HFMD | Older sibling controls | P-value2 | P-value3 |
|---|---|---|---|---|---|---|---|
CD3 T-cell | 2837.2 (2243.3, 3982.1) | 3536.3 (3196.6, 4450.2) | 0.01 | 2212.1 (1932.2, 2918.3) | 2704.5 (2040.0, 3452.0) | 0.03 | 0.01 |
CD4 T-cell | 2161.6 (1845.8, 4132.7) | 2488.5 (2165.5, 3379.0) | 0.48 | 1224.5 (1074.4, 2743.7) | 1373 (1041.0, 1804.0) | 0.12 | 0.01 |
CD8 T-cell | 534.0 (314.2, 824.6) | 970.0 (904.5, 1150.5) | <  0.01* | 911.7 (534.8, 1843.2) | 1243.5 (998.0, 1531.0) | 0.27 | 0.02 |
CD16 + CD56+ (NK cell) | 250.3 (123.9, 325.4) | 361.0 (239.5, 478.5) | 0.72 | 573.9 (342.7, 1267.3) | 379.5 (224.0, 1091.0) | 0.02 | 0.79 |
IgG | 3.2 (2.3, 4.1) | 6.2 (5.2, 7.0) | 0.68 | 9.7 (6.4, 11.6) | 9.5 (8.9, 10.6) | 0.12 | 0.09 |
IgA | <  0.3 | <  0.3 | 1 | 2.0 (1.0, 2.6) | 1.2 (0.9, 1.5) | <  0.01* | <  0.01* |
IgM | 0.4 (0.2, 0.6) | 0.2 (0.2, 0.3) | <  0.01*c | 2.5 (1.2, 3.2) | 1.1 (0.6, 1.2) | 0.05 | <  0.01* |
IL-1β | 730.1 (384.8, 937.5) | 61.9 (22.5, 71.5) | <  0.01*c | 1019.3 (776.2, 1832.9) | 88.8 (56.5, 138.2) | <  0.01*c | <  0.01*c |
IL-2R | 1516.4 (497.3, 2732.3) | 1438.5 (1277.5, 1556.5) | <  0.01*c | 1392.9 (476.8, 1732.2) | 485.0 (394.0, 669.1) | <  0.01*c | 0.03c |
IL-6 | 32.4 (28.2, 67.3) | 3.8 (3.1, 48.4) | <  0.01*c | 16.9 (14.3, 80.9) | 5.2 (2.8, 14.9) | <  0.01*c | 0.61c |
IL-8 | 63.6 (14.6, 1283.6) | 110.8 (19.7, 1866.0) | <  0.01*c | 58.2 (20.8, 1282.6) | 20.1 (7.7, 321.0) | <  0.01*c | 0.91c |
IL-10 | 26.4 (14.2, 46.8) | 17.5 (12.3, 53.1) | 0.01c | 79.3 (41.4, 135.4) | 2.5 (1.3, 32.5) | <  0.01*c | <  0.01*c |
TNF-α | 15.3 (9.5, 38.2) | 13.2 (11.0, 26.7) | <  0.01*c | 18.6 (11.6, 33.3) | 11.2 (8.9, 17.3) | <  0.01*c | 0.41c |