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Table 2 Routine blood test of neonates and paired older siblings with hand, foot, and mouth disease

From: Neonatal hand, foot, and mouth disease due to coxsackievirus A6 in Shanghai

Parameter Neonates with HFMD Neonate controls P-value1 Older sibling with HFMD Older sibling controls P-value2 P-value3
WBC count (×109/L) 8.5 (4.2, 12.8) 7.1 (5.5, 9.8) 0.51 15.5 (6.4, 20.6) 8.2 (6.7, 9.1) <  0.01* <  0.01*
RBC count (× 1012/L) 4.3 (3.2, 5.1) 4.1 (3.3, 4.6) 0.20 4.3 (3.5, 5.5) 4.8 (4.3, 5.4) 0.02 0.82
Platelet count (×109/L) 378.5 (164.6, 406.9) 349.0 (248.5, 398.0) 0.01 283.1 (233.7, 369.2) 267.2 (194.2, 426.7) 0.39 0.01
Leukomonocytes (%) 53.4 (24.8, 76.4) 54.6 (43.7, 61.4) 0.84 47.2 (30.5, 68.3) 47.1 (41.1, 61.7) 0.92 0.78
Monocytes (%) 11.2 (9.4, 14.7) 9.7 (7.8, 11.7) 0.12 10.3 (7.9, 17.4) 7.4 (5.7, 9.0) 0.12 0.21
Neutrophils (%) 26.6 (19.2, 49.2) 22.0 (13.7, 34.2) 0.48 38.6 (13.2, 78.4) 41.7 (31.9, 50.4) 0.21 <  0.01*
Haemoglobin (g/L) 103.2 (89.7, 118.1) 140.0 (107.0, 154.5) 0.05 118.1 (101.3, 127.3) 127.5 (121.0, 134.0) 0.17 0.92
  1. WBC White blood cells, RBC Red blood cells, P-value1T-test between neonatal HFMD cases and age-matched controls, P-value2T-test for the comparison between older siblings with HFMD and age-matched controls, P-value3T-test for the comparison between neonatal and older-sibling HFMD cases
  2. *Statistical significance