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Table 2 Routine blood test of neonates and paired older siblings with hand, foot, and mouth disease

From: Neonatal hand, foot, and mouth disease due to coxsackievirus A6 in Shanghai

Parameter

Neonates with HFMD

Neonate controls

P-value1

Older sibling with HFMD

Older sibling controls

P-value2

P-value3

WBC count (×109/L)

8.5 (4.2, 12.8)

7.1 (5.5, 9.8)

0.51

15.5 (6.4, 20.6)

8.2 (6.7, 9.1)

<  0.01*

<  0.01*

RBC count (× 1012/L)

4.3 (3.2, 5.1)

4.1 (3.3, 4.6)

0.20

4.3 (3.5, 5.5)

4.8 (4.3, 5.4)

0.02

0.82

Platelet count (×109/L)

378.5 (164.6, 406.9)

349.0 (248.5, 398.0)

0.01

283.1 (233.7, 369.2)

267.2 (194.2, 426.7)

0.39

0.01

Leukomonocytes (%)

53.4 (24.8, 76.4)

54.6 (43.7, 61.4)

0.84

47.2 (30.5, 68.3)

47.1 (41.1, 61.7)

0.92

0.78

Monocytes (%)

11.2 (9.4, 14.7)

9.7 (7.8, 11.7)

0.12

10.3 (7.9, 17.4)

7.4 (5.7, 9.0)

0.12

0.21

Neutrophils (%)

26.6 (19.2, 49.2)

22.0 (13.7, 34.2)

0.48

38.6 (13.2, 78.4)

41.7 (31.9, 50.4)

0.21

<  0.01*

Haemoglobin (g/L)

103.2 (89.7, 118.1)

140.0 (107.0, 154.5)

0.05

118.1 (101.3, 127.3)

127.5 (121.0, 134.0)

0.17

0.92

  1. WBC White blood cells, RBC Red blood cells, P-value1T-test between neonatal HFMD cases and age-matched controls, P-value2T-test for the comparison between older siblings with HFMD and age-matched controls, P-value3T-test for the comparison between neonatal and older-sibling HFMD cases
  2. *Statistical significance