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Table 1 Evolution of biochemical parameters of liver injury

From: Histological demonstration of BSEP/ABCB11 inhibition in transient neonatal cholestasis: a case report

Laboratory test

0–24 h

24–72 h

5 day

3 weeks

1.5 months

3 months

6 months

12 months

16 months

45 months

ALT (U/L)

857 (<  67)

485 (<  67)

180 (<  67)

74 (<  67)

268 (<  59)

406 (<  59)

250 (<  45)

71 (<  45)

30 (<  45)

19 (<  54)

AST (U/L)

2145 (<  77)

697 (<  77)

98 (<  77)

89 (<  77)

261 (< 57)

304 (< 57)

112 (<  43)

59 (<  43)

30 (<  43)

28 (<  43)

LDH (U/L)

9082 (<  700)

4628 (<  700)

1583 (<  700)

391 (<  700)

301 (160–430)

306 (160–430)

n.m.

n.m.

257 (120–340)

257 (120–340)

Bilirubin total (mg/dL)

2.5 (<  1.5)

4.8 (<  1.5)

3.38 (<  1.5)

8.08 (<  1.5)

11.07 (0.1–1.2)

5.8 (0.1–1.2)

0.46 (0.1–1.2)

n.m.

0.17 (0.1–1.2)

0.35 (0.1–1.2)

Bilirubin conj. (mg/dL)

n.m.

n.m.

n.m.

n.m.

8.87 (<  0.2)

n.m.

n.m.

n.m.

n.m.

n.m.

AP (U/L)

108 (<  310)

103 (<  310)

n.m.

304 (<  310)

363 (<  380)

n.m.

n.m.

n.m.

127 (<  320)

130 (155–370)

GGT (U/L)

166 (<  216)

165 (<  216)

54 (<  216)

128 (<  216)

83 (<  162)

188 (<  162)

241 (<  76)

52 (<  76)

20 (<  38)

13 (<  38)

Lactate (mmol/L)

13.8 (0.5–2.7)

6.0 (0.5–2.7)

1.4 (0.5–2.7)

0.9 (0.5–2.7)

0.5 (0.5–2.7)

n.m.

n.m.

n.m.

n.m.

n.m.

PT (%)

18 (70–120)

34 (70–120)

78 (70–120)

82 (70–120)

n.m.

98 (70–120)

98 (70–120)

n.m.

n.m.

n.m.

  1. For each parameter, the age-dependent reference ranges are presented in brackets
  2. ALT alanine aminotransferase, AST aspartate aminotransferase, AP alkaline phosphatase, GGT gamma-glutamyl transferase, LDH lactate dehydrogenase, n.m. not measured, PT prothrombin time