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Table 1 Evolution of biochemical parameters of liver injury

From: Histological demonstration of BSEP/ABCB11 inhibition in transient neonatal cholestasis: a case report

Laboratory test 0–24 h 24–72 h 5 day 3 weeks 1.5 months 3 months 6 months 12 months 16 months 45 months
ALT (U/L) 857 (<  67) 485 (<  67) 180 (<  67) 74 (<  67) 268 (<  59) 406 (<  59) 250 (<  45) 71 (<  45) 30 (<  45) 19 (<  54)
AST (U/L) 2145 (<  77) 697 (<  77) 98 (<  77) 89 (<  77) 261 (< 57) 304 (< 57) 112 (<  43) 59 (<  43) 30 (<  43) 28 (<  43)
LDH (U/L) 9082 (<  700) 4628 (<  700) 1583 (<  700) 391 (<  700) 301 (160–430) 306 (160–430) n.m. n.m. 257 (120–340) 257 (120–340)
Bilirubin total (mg/dL) 2.5 (<  1.5) 4.8 (<  1.5) 3.38 (<  1.5) 8.08 (<  1.5) 11.07 (0.1–1.2) 5.8 (0.1–1.2) 0.46 (0.1–1.2) n.m. 0.17 (0.1–1.2) 0.35 (0.1–1.2)
Bilirubin conj. (mg/dL) n.m. n.m. n.m. n.m. 8.87 (<  0.2) n.m. n.m. n.m. n.m. n.m.
AP (U/L) 108 (<  310) 103 (<  310) n.m. 304 (<  310) 363 (<  380) n.m. n.m. n.m. 127 (<  320) 130 (155–370)
GGT (U/L) 166 (<  216) 165 (<  216) 54 (<  216) 128 (<  216) 83 (<  162) 188 (<  162) 241 (<  76) 52 (<  76) 20 (<  38) 13 (<  38)
Lactate (mmol/L) 13.8 (0.5–2.7) 6.0 (0.5–2.7) 1.4 (0.5–2.7) 0.9 (0.5–2.7) 0.5 (0.5–2.7) n.m. n.m. n.m. n.m. n.m.
PT (%) 18 (70–120) 34 (70–120) 78 (70–120) 82 (70–120) n.m. 98 (70–120) 98 (70–120) n.m. n.m. n.m.
  1. For each parameter, the age-dependent reference ranges are presented in brackets
  2. ALT alanine aminotransferase, AST aspartate aminotransferase, AP alkaline phosphatase, GGT gamma-glutamyl transferase, LDH lactate dehydrogenase, n.m. not measured, PT prothrombin time