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Table 1 Clinical, laboratory, ultrasonographic, hepatobiliary scintigraphy characteristics of the derivation cohort

From: Development and validation of bile acid profile-based scoring system for identification of biliary atresia: a prospective study

ParametersBANon-BAControlPBA vs Non-BA
n = 34n = 32n = 37Pa
Baseline characters
 Maternal age (year) (Mean, SD)30 (4)26 (3)30 (4)0.4370.272
 Birth weight (g) (Mean, SD)3232 (461)2931 (770)3393 (477)0.2410.218
 Age at admission (day) (Mean, SD)51 (16)50 (13)42 (12)0.1510.176
 Weight at admission (g) (Mean, SD)4514 (844)3951 (818)4264 (1014)0.3060.096
 Parity (N, %)   0.0130.981
  024 (70.6)23 (71.9)28 (75.7)  
   ≥ 110 (29.4)9 (28.1)9 (24.3)  
 Sex (N, %)   0.1170.051
  Male13 (38.2)20 (62.5)16 (43.2)  
  Female21 (61.8)12 (37.5)21 (56.8)  
Clinical measures
 Recurrent jaundice (N, %)4 (11.8)9 (28.1)//0.097
 Clay stool (N, %)23 (67.7)7 (21.9)//< 0.001
 Hepatomegaly (N, %)19 (55.9)9 (28.1)//0.024
 Splenomegaly (N, %)7 (20.6)7 (21.9)//0.899
Liver function test (Median, IQR)
 Total bile acid (μmol/L)105 (73, 132)82 (68, 124.5)8 (6, 15)< 0.0010.141
 Alanine transaminase (U/L)111.5 (72, 235)118.5 (87.5, 184)40 (30, 50)< 0.0010.963
 Aspartate transaminase (U/L)219 (133, 308)170 (132.5, 296.5)50 (39, 61)< 0.0010.572
 Alkaline phosphatase (U/L)541.5 (446, 619)510.5 (373, 618.5)213 (171, 246)< 0.0010.959
 Total bilirubin (μmol/L)162.5 (143, 194)141.5 (101, 220.5)24 (16, 47)< 0.0010.047
 Direct bilirubin (μmol/L)107 (79, 124)96 (49, 131)0 (0, 0)< 0.0010.342
 Albumin (g/L)39 (35, 41)36 (34, 40)38 (34, 39)0.1530.091
 γ-glutamyl transferase (U/L)440 (222, 731)117 (85, 273)67 (41, 94)< 0.001< 0.001
Ultrasonography findings
 Abnormal gallbladder (N, %)14 (41.2)3 (9.4)//0.003
 Triangular cord sign (N, %)3 (8.8)2 (6.3)//0.693
 Internal diameter of common hepatic duct(mm) (Median, IQR)1.2 (0.6, 1.5)1.3 (1.0, 1.4)//0.712
Positive finding in hepatobiliary scintigraphy (N, %)29 (85.3)14 (43.8)//< 0.001
  1. BA Biliary atresia
  2. a Variance analysis, Mann-Whitney test or Chisq test of BA and non-BA group