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Table 5 Tacrolimus pharmacokinetic data in relation to CYP3A5 and SXR A7635G gene polymorphisms in the 49 patients of the study

From: CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant

 

Days

CYP3A5*3

SXR A7635G

AA/AG (12 patients)

GG (37 patients)

AA (16 patients)

AG (24 patients)

GG (9 patients)

Dose/kg (mg/kg)

day 7

0.17 ± 0.10

0.15 ± 0.06

0.18 ± 0.10

0.14 ± 0.04

0.16 ± 0.06

day 30

0.18 ± 0.10

0.13 ± 0.06

0.17 ± 0.11

0.14 ± 0.05

0.14 ± 0.07

day 90

0.15 ± 0.09

0.11 ± 0.06

0.14 ± 0.10

0.10 ± 0.05

0.12 ± 0.07

day 180

0.13 ± 0.08

0.09 ± 0.06

0.11 ± 0.09

0.08 ± 0.04

0.11 ± 0.07

day 360

0.11 ± 0.08

0.07 ± 0.05

0.10 ± 0.08

0.07 ± 0.03

0.08 ± 0.07

C0/(dose/kg) (ng/ml)/(mg/kg)

day 7

67.52 ± 48.67*

80.67 ± 58.46

95.47 ± 82.73

64.13 ± 24.06

79.11 ± 53.07

day 30

73.83 ± 105.88*

111.45 ± 70.37

103.21 ± 87.98

97.40 ± 60.02

111.86 ± 118.66

day 90

92.19 ± 139.61*

114.52 ± 68.18

103.33 ± 76.67

108.79 ± 64.90

119.26 ± 157.82

day 180

70.48 ± 137.70*

137.70 ± 103.44

121.30 ± 101.09

127.20106.22

104.06 ± 70.10

day 360

72.56 ± 182.92*

182.92 ± 199.75

192.34 ± 283.35

142.93 ± 103.30

121.24 ± 78.97

  1. Data are expressed as mean ± S.D. * p-value < 0.05 at Mann Whitney test
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BMC Pediatrics

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