Table 5 Summary of meta-analyses for the incidence of VOD
Type of AUC | Cut-off value (μM*min/L) | RR (95% CI) | Number of studies | Number of participants in treatment group | Number of participants in control group | I2% |
|---|---|---|---|---|---|---|
AUC first dose | ≤1350 versus>1350 | 0.562 (0.126,2.496) | 3 | 51 | 23 | 26.96% |
≤1500 versus>1500 | 0.761 (0.435,1.333) | 4 | 87 | 44 | 0 | |
AUC mean | ≤1350 versus>1350 | 0.370 (0.205,0.666) | 7 | 207 | 61 | 0 |
≤1500 versus>1500 | 0.409 (0.182,0.920) | 5 | 163 | 28 | 0 |