Type of AUC | Cut-off value (μM*min/L) | RR (95% CI) | Number of studies | Number of participants in treatment group | Number of participants in control group | I2% |
---|---|---|---|---|---|---|
AUC first dose | < 800 verse ≥800 | 2.664 (0.857, 8.282) | 4 | 24 | 67 | 0 |
< 900 verse ≥900 | 2.208 (0.686, 7.107) | 5 | 73 | 100 | 0 | |
< 1000verse ≥1000 | 1.544 (0.315, 7.561) | 4 | 48 | 43 | 0 | |
<1225verse ≥1225 | 1.007 (0.222, 4.578) | 4 | 66 | 25 | 0 | |
AUC mean | < 800 verse ≥800 | 5.296 (1.389, 20.191) | 3 | 22 | 78 | 0 |
< 900 verse ≥900 | 3.666 (1.419, 9.467) | 7 | 59 | 216 | 0 | |
<1000verse ≥1000 | 1.245 (0.267, 5.809) | 4 | 62 | 38 | 0 | |
<1225verse ≥1225 | 0.559 (0.125, 2.505) | 4 | 78 | 22 | 0 |