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Table 3 Summary of meta-analyses for the incidence of graft failure

From: Busulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: a meta-analysis

Type of AUC

Cut-off value (μM*min/L)

RR (95% CI)

Number of studies

Number of participants in treatment group

Number of participants in control group

I2%

AUC first dose

< 800 verse ≥800

2.664 (0.857, 8.282)

4

24

67

0

< 900 verse ≥900

2.208 (0.686, 7.107)

5

73

100

0

< 1000verse ≥1000

1.544 (0.315, 7.561)

4

48

43

0

<1225verse ≥1225

1.007 (0.222, 4.578)

4

66

25

0

AUC mean

< 800 verse ≥800

5.296 (1.389, 20.191)

3

22

78

0

< 900 verse ≥900

3.666 (1.419, 9.467)

7

59

216

0

<1000verse ≥1000

1.245 (0.267, 5.809)

4

62

38

0

<1225verse ≥1225

0.559 (0.125, 2.505)

4

78

22

0

  1. CI Confidence interval