Table 1 Demographic, disease status and medication information among neonatal patients using digoxin on modeling dataset or validation dataset

 Number of observations (male/female)

139 (81/58)

29 (13/16)

 Number of patients (male/female)

71 (40/31)

19 (7/12)

 Gender (Male/Female)

81/58

13/16

 Postnatal age (week)

36.35 ± 8.08^b, (34)^c

38.41 ± 5.14^b, (37)^c

 Total body weight (kg)

1.73 ± 0.90^b, (1.44)^c

1.88 ± 0.72^b, (1.76)^c

 CHF

54 (38.8)

11 (37.9)

 DCM

9 (6.5)

4 (13.8)

 PH

11 (7.9)

7 (24.1)

 VSD

16 (11.5)

9 (28.1)

 Ibuprofen

61 (38/23)

11 (3/8)

 Captopril

6 (6/0)

4 (4/0)

 Furosemide

24 (20/4)

5 (4/1)

 Digoxin dose (mcg∙kg⁻¹∙d⁻¹)

5.90 ± 1.93, (5.19)

5.66 ± 1.81, (5.17)

 Drug concentrations (ng/mL)

1.25 ± 0.38, (1.2)

1.14 ± 0.24, (1.06)