Table 1 Main clinical and laboratory features of patients with IgA vasculitis (HSP) who developed juvenile Systemic Lupus Erythematosus (jSLE)
Pat | G | Age at HSP | Type of skin rash | GI | Jointsa (number) | Renal | HSP Recur | Age at SLE | SLE Criteria (ACR) | Renal (g/d) | ANA/ DNA | C3 C4 | IgG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | M | 9y 7 m | Purpura | Angina | Knees Ankle (4) | Hem, Prot, Nephrotic | No | 9y 10 m | CC, Nephritis, Serositis, Hemolytic A, Lymphopenia | Hem Prot (0.6) | +/+ | 43.1 2.4 | 2020 |
2 | F | 14y 4 m | Purpura + Petechiae | – | Wrist Ankle (4) | – | yes (1)b | 15y 2 m | MR, Photosensitivity, Oral ulcers, Arthritis, Nephritis, Lymphopenia | Hem Prot (1.8) Casts | +/+ | 47.0 4.0 | 1670 |
3 | F | 3y 3 m | Purpura | – | Knees Ankle (2) | Prot Nephrotic | No | 3y 6 m | Arthritis, Nephritis, Serositis, Hemolytic A | Prot (0.6) | +/+ | 17.9 1.6 | 3240 |
4 | F | 12y 4 m | Purpura + Ecchymos | Angina | Knees Ankle (4) | Hem, Prot, Nephrotic | No | 12y 6 m | Arthritis, Nephritis | Hem Prot (0.4) Casts | +/+ | 42.0 6.1 | 2990 |
5 | F | 9y 11 m | Purpura | – | Ankle (1) | Hem | No | 10y 1 m | MR, Photosensitivity, Oral ulcers, Arthritis, Nephritis, Hemolytic A, Lymphopenia | Prot (1.3) | +/+ | 49.9 6.2 | 620 |
6 | F | 13y 7 m | Purpura | Angina Surgery | Knees Ankle Elbow (6) | Hem, Prot, Nephrotic | yes (1)b | 14y | MR, Oral ulcers, Arthritis, Nephritis, Serositis, Hemolytic A, Lymphopenia | Hem Prot (1.0) | +/+ | 43.0 7.2 | 1470 |
7 | F | 12y 5 m | Purpura | – | Knees Ankle (2) | Prot Nephrotic | No | 12y 7 m | Arthritis, Nephritis, Hemolytic A, Lymphopenia | Prot (0.9) | +/+ | 24.6 1.5 | 2580 |
8 | F | 13y 2 m | Purpura + Petechiae | – | Knees Ankle Elbow (3) | – | No | 13y 5 m | MR, Nephritis | Prot (0.6) | +/+ | 32.0 1.7 | 2974 |
9 | F | 9y 11 m | Purpura + Ecchymos | Angina | Ankle (1) | Hem, Prot Nephritic | yes (1) | 11y 7 m | MR, Photosensitivity, Arthritis, Nephritis | Hem Casts | +/+ | 55.9 5.6 | 1170 |
10 | M | 11y 11 m | Purpura | – | Ankle (1) | Hem, Prot, Nephrotic | No | 12y 2 m | Arthritis, Nephritis, Lymphopenia | Prot (1.5) Casts | +/+ | 58.5 1.4 | 2260 |
11 | M | 9y 9 m | Purpura | Angina | Knees Ankle Elbow (3) | – | yes (4)c | 10y 1 m | Arthritis, Nephritis, Hemolytic A, Lymphopenia | Hem Prot (2.0) Casts | +/+ | 18.3 6.8 | 2570 |
12 | F | 10y 7 m | Purpura | Angina | Ankle (1) | Hem | yes (1) | 12y | MR, Oral ulcers, Nephritis, Lymphopenia | Prot (0.6) Casts | +/+ | 61.2 9.1 | 1920 |
13 | F | 6y 3 m | Purpura | Angina | Knees Ankle (4) | Hem | yes (1) | 6y 7 m | Arthritis, Nephritis, Lymphopenia | Hem Prot | +/+ | 40.0 8.0 | 1680 |
14 | F | 5y 2 m | Purpura | – | Knees Ankle (4) | – | No | 7y | MR, Oral ulcers, Arthritis, Nephritis, Hemolytic A, Lymphopenia | Hem Prot Casts | +/+ | 34.0 3.2 | 1871 |
15 | F | 14y | Purpura | – | Ankle (2) | Nephrotic/ Nephritic | yes (1) | 14y 3 m | Arthritis, Nephritis, Lymphopenia | Hem Prot (1.9) | +/+ | 24.7 1.54 | 2460 |