Early prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigation

Table 1 Clinical predictor variables

Patient Demographics	Antenatal Risk Factors	Early Postnatal Illness Severity	Diagnoses in Early Postnatal Period^a	Medications (by date, dose^b, route)	Physiologic Measures (date)
Birth GA Birth weight z-score for GA Sex Race/Ethnicity Transported from outside birth hospital Singleton or multiple gestation Social status (BSMSS)	Maternal corticosteroid administration Maternal magnesium sulfate administration Pre-eclampsia Clinical and histological chorioamnionitis	Apgar scores Score for Neonatal Acute Physiology (SNAPPE-II) variables [72] Variables from NRN Extremely Preterm Outcomes Prediction Tool [73, 74]	IVH Grade 3 or 4 (only included in models after routine ultrasound at 7 postnatal days) Necrotizing enterocolitis Pneumothorax Spontaneous intestinal perforation Seizure	Indomethacin Caffeine Diuretics Inhaled corticosteroids Surfactant treatment Vitamin A Total daily fluid intake^b	Daily respiratory support modality Mean daily FiO₂ Oxygen saturation index Mean arterial blood pressure^b Daily urine output^b

^a Will only include diagnoses in models that were present prior to model specific week during postnatal weeks 1 to 4
^b Will weight adjust by kg
GA gestational age, BSMSS Barratt Simplified Measure of Social Status, IVH intraventricular hemorrhage

ISSN: 1471-2431