Does the fortified milk with high iron dose improve the neurodevelopment of healthy infants? Randomized controlled trial

Iglesias Vázquez, Lucía; Canals, Josefa; Voltas, Núria; Jardí, Cristina; Hernández, Carmen; Bedmar, Cristina; Escribano, Joaquín; Aranda, Núria; Jiménez, Rosa; Barroso, Josep Maria; Ribot, Blanca; Arija, Victoria

doi:10.1186/s12887-019-1679-0

Table 2 Characteristics of anthropometry, biochemistry and neurobehavioral development at 6 and 12 months, according to the intervention

From: Does the fortified milk with high iron dose improve the neurodevelopment of healthy infants? Randomized controlled trial

	6 MONTHS			12 MONTHS			VARIATION FROM 6 TO 12 MONTHS ∆ 12–6 months
	Formula milk (high dose of Fe) n = 105	Formula milk (low dose of Fe) n = 28	p	Formula milk (high dose of Fe) n = 105	Formula milk (low dose of Fe) n = 28	p	Formula milk (high dose of Fe) n = 105	Formula milk (low dose of Fe) n = 28	p
Weight, g	8051.8 (939.5)	7545.0 (715.8)	0.009	10,143.0 (1218.8)	9628.0 (1113.1)	0.048	2089.5 (562.1)	2014.0 (767.2)	0.578
Length, cm	67.7 (2.5)	66.3 (2.5)	0.011	76.2 (2.9)	74.4 (2.8)	0.007	8.5 (2.3)	8.3 (1.6)	0.636
Head Circumference, cm	43.7 (1.4)	42.9 (0.9)	0.002	46.5 (1.5)	45.7 (1.3)	0.012	2.8 (0.8)	2.8 (0.6)	0.912
Body Mass Index, kg/m²	17.5 (1.4)	17.2 (1.5)	0.227	17.5 (1.6)	17.4 (1.8)	0.872	−0.1 (1.1)	0.0 (1.3)	0.637
Hemoglobin, g/dL	11.7 (1.0)	11.5 (1.0)	0.479	12.0 (0.7)	11.8 (1.0)	0.218	0.4 (0.8)	0.3 (0.9)	0.557
Mean Corpuscular Volume, fl	77.5 (4.0)	78.0 (4.6)	0.589	79.0 (4.0)	78.1 (5.4)	0.344	1.4 (3.2)	0.1 (2.3)	0.073
Serum Iron, μmol/L	10.9 (4.5)	11.1 (5.2)	0.876	11.5 (4.6)	11.6 (5.0)	0.923	0.6 (5.6)	0.5 (6.4)	0.929
Serum Ferritin, μg/L^#	27.7 (2.0)	33.4 (2.1)	0.021	21.5 (1.7)	19.1 (1.8)	0.001	−6.2 (2.0)	−14.3 (2.1)	0.055
Transferrin Saturation, %TS	16.3 (7.3)	18.7 (9.8)	0.182	17.0 (6.8)	17.1 (9.4)	0.965	0.6 (8.4)	−2.4 (7.0)	0.027
Serum Ferritin < 12 μg/L, %*	6.5	0	0.408	6.9	12.5	0.595	0.4	12.5	< 0.001
Iron Deficiency, %*	1.1	3.8	0.916	5.9	16.7	0.165	4.8	12.9	0.053
Iron Deficiency Anemia, %*	4.3	0	0.642	1.1	4.2	0.884	−3.2	4.2	< 0.001
Infections, %	3.1	2.0	0.650	25.3	25.0	0.812	22.2	23.0	0.782
Mental Development Index	94.8 (9.6)	93.0 (12.9)	0.421	99.1 (12.3)	95.8 (8)	0.217	4.6 (13.1)	2.5 (15.1)	0.509
Psychomotor Development Index	85.7 (13.9)	81.5 (10.1)	0.149	90.8 (12.8)	86.6 (11.7)	0.146	5.4 (15.7)	5.1 (12.8)	0.936

Data are expressed in Mean (SD) or in %
*In the variation from 6 to 12 months, a percentage close to zero or negative is a good result
^#Geometric mean

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ISSN: 1471-2431

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