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Table 2 Characteristics of anthropometry, biochemistry and neurobehavioral development at 6 and 12 months, according to the intervention

From: Does the fortified milk with high iron dose improve the neurodevelopment of healthy infants? Randomized controlled trial

  6 MONTHS 12 MONTHS VARIATION FROM 6 TO 12 MONTHS ∆ 12–6 months  
Formula milk (high dose of Fe) n = 105 Formula milk (low dose of Fe) n = 28 p Formula milk (high dose of Fe) n = 105 Formula milk (low dose of Fe) n = 28 p Formula milk (high dose of Fe) n = 105 Formula milk (low dose of Fe) n = 28 p
Weight, g 8051.8 (939.5) 7545.0 (715.8) 0.009 10,143.0 (1218.8) 9628.0 (1113.1) 0.048 2089.5 (562.1) 2014.0 (767.2) 0.578
Length, cm 67.7 (2.5) 66.3 (2.5) 0.011 76.2 (2.9) 74.4 (2.8) 0.007 8.5 (2.3) 8.3 (1.6) 0.636
Head Circumference, cm 43.7 (1.4) 42.9 (0.9) 0.002 46.5 (1.5) 45.7 (1.3) 0.012 2.8 (0.8) 2.8 (0.6) 0.912
Body Mass Index, kg/m2 17.5 (1.4) 17.2 (1.5) 0.227 17.5 (1.6) 17.4 (1.8) 0.872 −0.1 (1.1) 0.0 (1.3) 0.637
Hemoglobin, g/dL 11.7 (1.0) 11.5 (1.0) 0.479 12.0 (0.7) 11.8 (1.0) 0.218 0.4 (0.8) 0.3 (0.9) 0.557
Mean Corpuscular Volume, fl 77.5 (4.0) 78.0 (4.6) 0.589 79.0 (4.0) 78.1 (5.4) 0.344 1.4 (3.2) 0.1 (2.3) 0.073
Serum Iron, μmol/L 10.9 (4.5) 11.1 (5.2) 0.876 11.5 (4.6) 11.6 (5.0) 0.923 0.6 (5.6) 0.5 (6.4) 0.929
Serum Ferritin, μg/L# 27.7 (2.0) 33.4 (2.1) 0.021 21.5 (1.7) 19.1 (1.8) 0.001 −6.2 (2.0) −14.3 (2.1) 0.055
Transferrin Saturation, %TS 16.3 (7.3) 18.7 (9.8) 0.182 17.0 (6.8) 17.1 (9.4) 0.965 0.6 (8.4) −2.4 (7.0) 0.027
Serum Ferritin < 12 μg/L, %* 6.5 0 0.408 6.9 12.5 0.595 0.4 12.5 < 0.001
Iron Deficiency, %* 1.1 3.8 0.916 5.9 16.7 0.165 4.8 12.9 0.053
Iron Deficiency Anemia, %* 4.3 0 0.642 1.1 4.2 0.884 −3.2 4.2 < 0.001
Infections, % 3.1 2.0 0.650 25.3 25.0 0.812 22.2 23.0 0.782
Mental Development Index 94.8 (9.6) 93.0 (12.9) 0.421 99.1 (12.3) 95.8 (8) 0.217 4.6 (13.1) 2.5 (15.1) 0.509
Psychomotor Development Index 85.7 (13.9) 81.5 (10.1) 0.149 90.8 (12.8) 86.6 (11.7) 0.146 5.4 (15.7) 5.1 (12.8) 0.936
  1. Data are expressed in Mean (SD) or in %
  2. *In the variation from 6 to 12 months, a percentage close to zero or negative is a good result
  3. #Geometric mean