Table 5 Monte Carlo Simulation Results for Neonates Weighing ≤ 850 g
Dosing Regimen | Target Peak Serum Concentration (mg/L) | Target Trough Serum Concentration (mg/L) | Peak:Minimum Inhibitory Concentration Ratio | |||||
|---|---|---|---|---|---|---|---|---|
Dose (mg/kg) | Dosing Interval (h) | 5–10 | 12–20 | 15–20 | ≥ 20 | ≤ 2 | ≤ 0.5 | ≥ 8 |
2.5a | 24 | 68.76% | 0.12% | 0.01% | 0.00% | 81.16% | 5.18% | 4.21% |
3.5a | 24 | 80.45% | 4.61% | 0.51% | 0.01% | 58.24% | 1.68% | 11.26% |
3.0 | 48 | 69.05% | 0.02% | 0.00% | 0.00% | 99.89% | 78.65% | 3.26% |
3.5b | 48 | 86.31% | 0.27% | 0.00% | 0.00% | 99.74% | 71.89% | 6.35% |
4.0 | 48 | 87.81% | 1.53% | 0.07% | 0.00% | 99.45% | 65.51% | 9.30% |
4.5 | 48 | 78.22% | 5.12% | 0.40% | 0.00% | 99.01% | 59.83% | 12.54% |
5.0 | 48 | 62.65% | 12.44% | 1.53% | 0.02% | 98.42% | 53.62% | 16.18% |
5.5 | 48 | 45.62% | 23.47% | 4.10% | 0.12% | 97.69% | 49.95% | 20.08% |
6.0 | 48 | 30.54% | 36.89% | 8.66% | 0.42% | 96.76% | 45.74% | 24.21% |
6.5 | 48 | 18.92% | 50.59% | 15.39% | 1.13% | 95.72% | 41.94% | 28.74% |
7.0 | 48 | 11.15% | 62.11% | 23.60% | 2.61% | 94.51% | 38.77% | 33.22% |
7.5 | 48 | 6.10% | 70.60% | 32.27% | 5.19% | 93.14% | 35.73% | 37.96% |
8.0 | 48 | 3.16% | 74.94% | 39.79% | 9.10% | 91.71% | 32.96% | 42.66% |
8.0c | 72 | 4.62% | 73.37% | 35.31% | 5.94% | 99.84% | 87.65% | 39.55% |
8.5c | 72 | 2.41% | 76.38% | 42.25% | 10.04% | 99.79% | 86.31% | 43.92% |
9.0c | 72 | 1.10% | 75.99% | 47.24% | 15.56% | 99.73% | 84.88% | 48.44% |
9.5 | 72 | 0.45% | 72.46% | 49.45% | 22.35% | 99.65% | 83.46% | 52.81% |
10 | 72 | 0.10% | 66.97% | 49.27% | 30.06% | 99.55% | 82.07% | 56.95% |