Head ultrasound, CT or MRI? The choice of neuroimaging in the assessment of infants with congenital cytomegalovirus infection

Table 3 Clinical findings and neuroimaging abnormalities (HUS, CT, or MRI)

	Normal (n = 18)	Abnormal (n = 28)	p
Sensineural hearing loss^a	5 (27.8%)	15 (53.3%)	0.09
Chorioretinitis	0	1 (6.7%)	NA
Microcephaly	2 (13.3%)	3 (12%)	0.90
Clinically apparent symptoms^b	7 (38.9%)	19 (60.7%)	0.14
Laboratory abnormalities^c	5 (27.8%)	17 (66.7%)	0.03
Prematurity (< 37 weeks gestational age)	16 (88%)	21 (77.7%)	0.43
Baseline viral load (qPCR) (copies/ml)	69,104	98,040	0.17

^aDefined as a unilateral or bilateral hearing threshold of > 40 dB for at least 2 of the frequencies tested, using a combined protocol of automated distorsion product otoacoustic emissions (DPOAE-A) and automated auditory brainstem response (A-ABR), followed by brainstem auditory evoked potentials by three weeks of age
^bClinically apparent symptoms: Microcephaly, IUGR, hepatomegaly, splenomegaly, petechiea or purpura, jaundice
^cLaboratory abnormalities: Any of persistent thrombocytopenia, hepatitis, hyperbilirubinemia

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