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Table 3 Clinical findings and neuroimaging abnormalities (HUS, CT, or MRI)

From: Head ultrasound, CT or MRI? The choice of neuroimaging in the assessment of infants with congenital cytomegalovirus infection

  Normal (n = 18) Abnormal (n = 28) p
Sensineural hearing lossa 5 (27.8%) 15 (53.3%) 0.09
Chorioretinitis 0 1 (6.7%) NA
Microcephaly 2 (13.3%) 3 (12%) 0.90
Clinically apparent symptomsb 7 (38.9%) 19 (60.7%) 0.14
Laboratory abnormalitiesc 5 (27.8%) 17 (66.7%) 0.03
Prematurity (< 37 weeks gestational age) 16 (88%) 21 (77.7%) 0.43
Baseline viral load (qPCR) (copies/ml) 69,104 98,040 0.17
  1. aDefined as a unilateral or bilateral hearing threshold of > 40 dB for at least 2 of the frequencies tested, using a combined protocol of automated distorsion product otoacoustic emissions (DPOAE-A) and automated auditory brainstem response (A-ABR), followed by brainstem auditory evoked potentials by three weeks of age
  2. bClinically apparent symptoms: Microcephaly, IUGR, hepatomegaly, splenomegaly, petechiea or purpura, jaundice
  3. cLaboratory abnormalities: Any of persistent thrombocytopenia, hepatitis, hyperbilirubinemia