Table 1 Clinical characteristics for responders and non-responders for ibuprofen treatment for PDA
Demographics | Responders | Non-Responders | p valuea |
|---|---|---|---|
(n = 9) | (n = 9) | ||
Gestational age (weeks) | 27.7 (27.1–29.9) | 27.4 (26.1–27.9) | 0.161 |
Weight (g) | 1135 (913–1318) | 1015 (830–1083) | 0.222 |
Apgar at 1 min | 7 (5–8) | 6 (3–7) | 0.077 |
Apgar at 5 min | 9 (7–9) | 9 (8–9) | 0.931 |
Male | 6 (67%) | 2 (22%) | 0.153 |
Cesarean section | 6 (67%) | 7 (78%) | 1.000 |
Small for gestational age | 2 (22%) | 1 (11%) | 1.000 |
Echocardiography prior to ibuprofen treatment | |||
PDA diameter (mm) | 2.05 (1.78–2.46) | 2.20 (1.70–3.23) | 0.666 |
PDA diameter to weight (mm/kg) | 2.04 (1.40–2.54) | 2.26 (1.56–3.57) | 0.340 |
PDA maximum flow velocity (m/s) | 2.21 (1.59–2.60) | 1.82 (1.30–2.52) | 0.613 |
LA/Ao ratio | 1.47 (1.27–1.76) | 1.50 (1.44–1.87) | 0.370 |
Fractional shortening (%) | 41.0 (36.0–44.5) | 39.0 (34.2–43.8) | 0.661 |
Condition prior to ibuprofen treatment | |||
Post-natal age at dose #1 (day) | 3.0 (3.0–4.0) | 4.0 (3.0–6.5) | 0.222 |
Oral ibuprofen | 8 (89%) | 7 (78%) | 1.000 |
Respiratory support | 0.183 | ||
Non-invasive ventilation | 5 (56%) | 2 (22%) | |
Conventional ventilation | 4 (44%) | 5 (56%) | |
High frequency ventilation | 0 (0%) | 2 (22%) | |