Fig. 2

Trends charts of CO_EC, HR_EC and SV_EC for responders (gray line) and non-responders (black line) through ibuprofen treatment. Three gray bands indicate the time of each ibuprofen administration. Although there was no remarkable alteration of CO_EC, HR_EC and SV_EC within each group, non-responders had significantly higher CO_EC than responders through the course (between-subject p = 0.005) (¶), especially at the timing prior to dose #1 ibuprofen, 18–24 h post dose #2 and 18–24 h post dose #3, respectively (*). CO_EC, cardiac output; HR_EC, heart rate; SV_EC, stroke volume; all measured by electrical cardiometry