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Table 2 The complications or comorbidities of NEC infants treated (with/without) probiotics in this study

From: Probiotics may not prevent the deterioration of necrotizing enterocolitis from stage I to II/III

Variables

Total (n = 231)

Before matching

After matchinga

With (n = 108)

Without (n = 123)

P

With (n = 81)

Without (n = 81)

P

NRDS, %(n)

7.4 (17)

8.3 (9)

6.5 (8)

0.595

7.4 (6)

6.2 (5)

0.755

Apnea, %(n)

6.1 (14)

8.3 (9)

4.1 (5)

0.175

6.2 (5)

3.7 (3)

0.717

Respiratory failure, %(n)

16.0 (37)

14.8 (16)

17.1 (21)

0.641

13.6 (11)

16.0 (13)

0.658

Pulmonary hemorrhage, %(n)

5.2 (12)

4.6 (5)

5.7 (7)

0.717

4.9 (4)

7.4 (6)

0.514

Sepsis, %(n)

31.2 (72)

37.0 (40)

26.0 (32)

0.071

39.5 (32)

32.1 (26)

0.325

Septic shock, %(n)

2.6 (6)

1.9 (2)

3.3 (4)

0.552

2.5 (2)

4.9 (4)

0.677

Bacterial meningitis, %(n)

4.3 (10)

3.7 (4)

4.9 (6)

0.910

3.7 (3)

7.4 (6)

0.493

Congenital heart diseaseb, %(n)

44.2 (102)

45.4 (49)

43.1 (53)

0.728

46.9 (38)

46.9 (38)

1.000

Cardiac insufficiency, %(n)

1.3 (3)

1.9 (2)

0.8 (1)

0.910

1.2 (1)

1.2 (1)

1.000

MODS,%(n)

0.4 (1)

0 (0)

0.8 (1)

1.000a

0 (0)

1.2 (1)

1.000a

Anemia, %(n)

68.8 (159)

79.6 (86)

59.3 (73)

0.001

76.5 (62)

60.5 (49)

0.028

Coagulation disorder, %(n)

59.3 (137)

63.9 (69)

55.3 (68)

0.184

61.7 (50)

55.6 (45)

0.425

Thrombocytopenia, %(n)

21.2 (49)

22.2 (24)

20.3 (25)

0.725

23.5 (19)

23.5 (19)

1.000

  1. NRDS neonatal respiratory distress syndrome, MODS multiple organ dysfunction syndrome
  2. aWe performed 1:1 matching according to close gestational age (difference was ≤3 days) and birth weight (difference was ≤400 g)
  3. bThe congenital cardiac lesion: patent ductus arteriosus, ventricular septal defect or atrial septal defect. No special intervention was required in all cases after consultation with cardiologists and cardiac surgeons