Predictive value of the aspartate aminotransferase to platelet ratio index for parenteral nutrition associated cholestasis in extremely low birth weight infants

Table 2 Associations with laboratory test results and development of PNAC

Laboratory test results at each time point	PNAC
Laboratory test results at each time point	Yes	No	P -value
1 week
AST (mg/dL)	34.14 ± 21.34	43.09 ± 51.40	.821²
ALT (mg/dL)	6.41 ± 6.20	6.45 ± 4.56	.414²
AST/ALT	7.00 ± 5.27	7.37 ± 9.76	.867²
TB (mg/dL)	4.59 ± 2.34	4.16 ± 2.47	.119²
DB (mg/dL)	0.89 ± 0.87	0.63 ± 0.24	.015²
APRI	0.84 ± 0.81	0.64 ± 0.71	.003²
PLT (× 10³/μL)	139.98 ± 72.98	191.55 ± 70.45	.000²
2 weeks
AST	48.77 ± 38.47	55.01 ± 99.75	.178²
ALT	12.71 ± 12.55	12.32 ± 38.79	.218²
AST/ALT	4.84 ± 2.11	5.70 ± 3.28	.394²
TB	3.94 ± 1.80	3.98 ± 2.49	.603²
DB	1.23 ± 1.14	0.60 ± 0.25	.000²
APRI	1.52 ± 3.23	0.89 ± 3.42	.000²
PLT	159.75 ± 94.61	263.46 ± 114.66	.000²
3 weeks
AST	57.04 ± 49.33	37.87 ± 28.80	.003²
ALT	16.34 ± 13.56	15.52 ± 39.85	.011²
AST/ALT	3.91 ± 2.32	3.60 ± 1.99	.569²
TB	4.49 ± 2.60	3.38 ± 2.86	.004²
DB	1.78 ± 1.83	0.59 ± 0.31	.000²
APRI	1.72 ± 2.26	0.63 ± 1.23	.000²
PLT	165.10 ± 107.14	285.34 ± 143.80	.000²

All values are mean ± standard deviation. APRI (%) = (AST/40)/PLT × 100
Shapiro-Wilk’s test was employed for test of normality assumption
Abbreviations: TB total bilirubin, DB direct bilirubin, PLT platelets, AST aspartate aminotransferase, ALT alanine transaminase, APRI aspartate aminotransferase/platelet ratio index, PNAC parenteral nutrition–associated cholestasis
¹P values were derived from chi-square test
²P values were derived from Mann-Whitney’s U test

ISSN: 1471-2431