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Table 2 Associations with laboratory test results and development of PNAC

From: Predictive value of the aspartate aminotransferase to platelet ratio index for parenteral nutrition associated cholestasis in extremely low birth weight infants

Laboratory test results at each time point PNAC  
Yes No P -value
1 week
 AST (mg/dL) 34.14 ± 21.34 43.09 ± 51.40 .8212
 ALT (mg/dL) 6.41 ± 6.20 6.45 ± 4.56 .4142
 AST/ALT 7.00 ± 5.27 7.37 ± 9.76 .8672
 TB (mg/dL) 4.59 ± 2.34 4.16 ± 2.47 .1192
 DB (mg/dL) 0.89 ± 0.87 0.63 ± 0.24 .0152
 APRI 0.84 ± 0.81 0.64 ± 0.71 .0032
 PLT (× 103/μL) 139.98 ± 72.98 191.55 ± 70.45 .0002
2 weeks
 AST 48.77 ± 38.47 55.01 ± 99.75 .1782
 ALT 12.71 ± 12.55 12.32 ± 38.79 .2182
 AST/ALT 4.84 ± 2.11 5.70 ± 3.28 .3942
 TB 3.94 ± 1.80 3.98 ± 2.49 .6032
 DB 1.23 ± 1.14 0.60 ± 0.25 .0002
 APRI 1.52 ± 3.23 0.89 ± 3.42 .0002
 PLT 159.75 ± 94.61 263.46 ± 114.66 .0002
3 weeks
 AST 57.04 ± 49.33 37.87 ± 28.80 .0032
 ALT 16.34 ± 13.56 15.52 ± 39.85 .0112
 AST/ALT 3.91 ± 2.32 3.60 ± 1.99 .5692
 TB 4.49 ± 2.60 3.38 ± 2.86 .0042
 DB 1.78 ± 1.83 0.59 ± 0.31 .0002
 APRI 1.72 ± 2.26 0.63 ± 1.23 .0002
 PLT 165.10 ± 107.14 285.34 ± 143.80 .0002
  1. All values are mean ± standard deviation. APRI (%) = (AST/40)/PLT × 100
  2. Shapiro-Wilk’s test was employed for test of normality assumption
  3. Abbreviations: TB total bilirubin, DB direct bilirubin, PLT platelets, AST aspartate aminotransferase, ALT alanine transaminase, APRI aspartate aminotransferase/platelet ratio index, PNAC parenteral nutrition–associated cholestasis
  4. 1P values were derived from chi-square test
  5. 2P values were derived from Mann-Whitney’s U test
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