|
Laboratory test results at each time point
|
PNAC
| |
|---|
|
Yes
|
No
|
P -value
|
|---|
|
1 week
|
|
AST (mg/dL)
|
34.14 ± 21.34
|
43.09 ± 51.40
|
.8212
|
|
ALT (mg/dL)
|
6.41 ± 6.20
|
6.45 ± 4.56
|
.4142
|
|
AST/ALT
|
7.00 ± 5.27
|
7.37 ± 9.76
|
.8672
|
|
TB (mg/dL)
|
4.59 ± 2.34
|
4.16 ± 2.47
|
.1192
|
|
DB (mg/dL)
|
0.89 ± 0.87
|
0.63 ± 0.24
|
.0152
|
|
APRI
|
0.84 ± 0.81
|
0.64 ± 0.71
|
.0032
|
|
PLT (× 103/μL)
|
139.98 ± 72.98
|
191.55 ± 70.45
|
.0002
|
|
2 weeks
|
|
AST
|
48.77 ± 38.47
|
55.01 ± 99.75
|
.1782
|
|
ALT
|
12.71 ± 12.55
|
12.32 ± 38.79
|
.2182
|
|
AST/ALT
|
4.84 ± 2.11
|
5.70 ± 3.28
|
.3942
|
|
TB
|
3.94 ± 1.80
|
3.98 ± 2.49
|
.6032
|
|
DB
|
1.23 ± 1.14
|
0.60 ± 0.25
|
.0002
|
|
APRI
|
1.52 ± 3.23
|
0.89 ± 3.42
|
.0002
|
|
PLT
|
159.75 ± 94.61
|
263.46 ± 114.66
|
.0002
|
|
3 weeks
|
|
AST
|
57.04 ± 49.33
|
37.87 ± 28.80
|
.0032
|
|
ALT
|
16.34 ± 13.56
|
15.52 ± 39.85
|
.0112
|
|
AST/ALT
|
3.91 ± 2.32
|
3.60 ± 1.99
|
.5692
|
|
TB
|
4.49 ± 2.60
|
3.38 ± 2.86
|
.0042
|
|
DB
|
1.78 ± 1.83
|
0.59 ± 0.31
|
.0002
|
|
APRI
|
1.72 ± 2.26
|
0.63 ± 1.23
|
.0002
|
|
PLT
|
165.10 ± 107.14
|
285.34 ± 143.80
|
.0002
|
- All values are mean ± standard deviation. APRI (%) = (AST/40)/PLT × 100
- Shapiro-Wilk’s test was employed for test of normality assumption
- Abbreviations: TB total bilirubin, DB direct bilirubin, PLT platelets, AST aspartate aminotransferase, ALT alanine transaminase, APRI aspartate aminotransferase/platelet ratio index, PNAC parenteral nutrition–associated cholestasis
- 1P values were derived from chi-square test
- 2P values were derived from Mann-Whitney’s U test
