Table 1 Characteristics and clinical outcomes of neonates who received antibiotics pre- and post-ASP implementation
Characteristic | Pre-ASP cohort (N = 864) | During ASP cohort (N = 716) | p-value |
|---|---|---|---|
Birth weight (grams), median (IQR) | 1960 (1223, 2888) | 1920 (1180, 2910) | 0.49 |
Gestational age (weeks), median (IQR) | 33 (29, 37) | 33 (29, 37) | 0.55 |
SNAP II score, median (IQR) | 10 (5, 19) | 10 (5, 17) | 0.19 |
Length of stay, median (IQR) | 9 (4, 23) | 8.5 (4.0, 25.0) | 1.00 |
Antibiotic-free days, median (IQR) | 6.0 (1.0–21.0) | 6.0 (1.0–24.0) | 1.00 |
Death, N (%) | 32 (3.7) | 27 (3.8) | 1.00 |
Necrotizing enterocolitis, N (%) | 13 (1.5) | 19 (2.7) | 0.16 |
Candidemia, N (%) | 1 (0.1) | 1 (0.1) | 1.00 |
Culture-positive bacterial sepsis | 83 (9.6) | 64 (8.9) | 0.64 |
 Number of episodesa, N (%) | 103 (9.3) | 77 (8.3) | 0.45 |
 Episodes of bacteremia, N (%) | 58 (56.3) | 35 (45.4) | 0.15 |
 CoNS (N isolates) | 28 | 21 | 0.33 |
 Antibiotic days, median (IQR) | 10.0 (7.0, 13.2) | 9.0 (7.0,12.0) | 0.24 |
 Escherichia coli (N isolates) | 11 | 7 | 0.41 |
 Antibiotic days, median (IQR) | 17.0 (3.0,20.0) | 16.0 (5.5,20.0) | 0.89 |
Culture-negative late-onset sepsis, N (%) | 58 (6.7) | 56 (7.8) | 0.40 |
 Number of episodes a,b, N (%) | 192 (17.4) | 179 (19.4) | 0.30 |
 GA ≤ 28 weeks, N (%) | 124 (64.6) | 113 (63.1) | 0.86 |
 GA 29–33 weeks, N (%) | 33 (17.2) | 43 (24.0) | 0.15 |
 GA ≥ 34 weeks, N (%) | 35 (18.2) | 23 (12.8) | 0.19 |