Overall (n = 1271) | PDC < 80 (n = 1056) | PDC ≥ 80 (n = 215) | P value | ||||
---|---|---|---|---|---|---|---|
Age at RASI index date, mean (SD), year | 14.39 (4.86) | 14.40 (4.79) | 14.35 (5.19) | 0.513 | |||
< 4 | 58 | 4.56 | 45 | 4.26 | 13 | 6.05 | |
5–8 | 148 | 11.64 | 120 | 11.36 | 28 | 13.02 | |
9–12 | 209 | 16.44 | 180 | 17.05 | 29 | 13.49 | |
13–17 | 522 | 41.07 | 431 | 40.81 | 91 | 42.33 | |
≥ 18 | 334 | 26.28 | 280 | 26.52 | 54 | 25.12 | |
Sex, n, % | 0.003 | ||||||
Female | 621 | 48.86 | 496 | 46.97 | 125 | 58.14 | |
Male | 650 | 51.14 | 560 | 53.03 | 90 | 41.86 | |
CKD diagnosis, n, % | |||||||
CAKUT | 114 | 8.97 | 95 | 9.00 | 19 | 8.84 | 0.941 |
Glomerular diagnosis | 859 | 67.58 | 699 | 66.19 | 160 | 74.42 | 0.020 |
Diabetes/hypertension/gout- related nephropathy | 17 | 1.34 | 14 | 1.33 | 3 | 1.40 | 1.000 |
Nephrotic syndrome | 310 | 24.39 | 275 | 26.04 | 35 | 16.28 | 0.002 |
Glomerulonephritis | 301 | 23.68 | 267 | 25.28 | 34 | 15.81 | 0.003 |
Systemic lupus erythematous | 308 | 24.23 | 206 | 19.51 | 102 | 47.44 | <.0001 |
Others | 488 | 38.39 | 430 | 40.72 | 58 | 26.98 | <.0001 |
Nephritis | 134 | 10.54 | 115 | 10.89 | 19 | 8.84 | 0.464 |
Bartter syndrome/Fabry disease | 4 | 0.31 | 3 | 0.28 | 1 | 0.47 | 0.524 |
Proteinuria | 191 | 15.03 | 166 | 15.72 | 25 | 11.63 | 0.143 |
Hematuria | 148 | 11.64 | 131 | 12.41 | 17 | 7.91 | 0.062 |
CKD | 65 | 5.11 | 57 | 5.40 | 8 | 3.72 | 0.396 |
miscellaneous | 27 | 2.12 | 23 | 2.18 | 4 | 1.86 | 1.000 |
Baseline comorbid conditions, n, % | |||||||
Proteinuria | 1001 | 78.76 | 813 | 76.99 | 188 | 87.44 | <.000 |
Anemia | 202 | 15.89 | 146 | 13.83 | 56 | 26.05 | <.000 |
HTN-related | 1248 | 98.19 | 1040 | 98.48 | 208 | 96.74 | 0.092 |
Mineral bone disorders | 103 | 8.10 | 83 | 7.86 | 20 | 9.30 | 0.493 |
Diabetes | 100 | 7.87 | 86 | 8.14 | 14 | 6.51 | 0.488 |
Hyperlipidemia | 273 | 21.48 | 219 | 20.74 | 54 | 25.12 | 0.172 |
Time to RASI chronic therapy, year | |||||||
mean (SD) | 2.67 (2.55) | 2.55 (2.46) | 3.26 (2.89) | <.000 | |||
median (IQR) | 1.79 (0.74–3.71) | 1.68 (0.72–3.54) | 2.38 (1.07–4.57) |