Table 1 Clinical performance of POC PCR, laboratory PCR, bacterial culture, and POC RADT when compared with final results by sequencing for group A Streptococcus (n = 255)
Cobas Liat POC PCRa | Quidel QuickVue POC RADT | Bacterial culture | |||||||
|---|---|---|---|---|---|---|---|---|---|
Final resultb | Positive | Negative | Total | Positive | Negative | Total | Positive | Negative | Total |
Positive | 105 | 1 | 106 | 94 | 9 | 103 | 79 | 0 | 79 |
Negative | 5 | 144 | 149 | 16 | 136 | 152 | 31 | 144 | 175 |
Total | 110 | 145 | 255 | 110 | 145 | 255 | 110 | 144 | 254 |
Sensitivity n/N (%, 95 CI) | 105/110 (95.5%, 89.7–98.5) | 94/110 (85.5%, 77.5–91.5) | 79/110 (71.8%, 62.4–80.0) | ||||||
Specificity n/N (%, 95 CI) | 144/145 (99.3%, 96.2–99.9) | 136/145 (93.7%, 88.5–97.1) | 144/144 (100.0%, 97.5–100.0) | ||||||
PPV n/N (%, 95 CI) | 105/106 (99.1%, 94.9–99.9) | 94/103 (91.3%, 84.1–95.9) | 79/79 (100.0%, 95.4–100.0) | ||||||
NPV n/N (%, 95 CI) | 144/149 (96.6%, 92.3–98.9) | 136/152 (89.5%, 83.5–93.9) | 144/175 (82.3%, 75.8–87.6) | ||||||
OPA n/N (%, 95 CI) | 249/255 (97.6%, 94.9–99.1) | 230/255 (90.2%, 85.9–93.6) | 223/254 (87.8%, 83.1–91.6) | ||||||