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Table 2 Associations of insulin metabolism markers with carotid intima media thickness according to sex

From: Insulin metabolism markers are predictors of subclinical atherosclerosis among overweight and obese children and adolescents

  Multiple linear regression Multiple ordinal regression*
Standardized β P-value OR (95% CI) P-value
Fasting insulin (μU/ml)
 Boys
  Unadjusted 0.299 < 0.001 1.49 (1.10–2.01) 0.009
  Model 1 0.351 < 0.001 1.87 (1.24–2.81) 0.003
  Model 2 0.344 < 0.001 1.84 (1.22–2.79) 0.004
 Girls
  Unadjusted 0.010 0.911 1.21 (0.93–1.58) 0.154
  Model 1 −0.090 0.344 0.93 (0.67–1.29) 0.672
  Model 2 −0.116 0.242 0.89 (0.63–1.25) 0.506
HOMA-IR
 Boys
  Unadjusted 0.308 < 0.001 1.51 (1.12–2.04) 0.006
  Model 1 0.350 < 0.001 1.81 (1.22–2.70) 0.003
  Model 2 0.343 < 0.001 1.80 (1.20–2.68) 0.004
 Girls
  Unadjusted −0.006 0.951 1.18 (0.91–1.55) 0.215
  Model 1 −0.096 0.314 0.91 (0.66–1.27) 0.601
  Model 2 −0.122 0.217 0.87 (0.61–1.23) 0.425
QUICKI
 Boys
  Unadjusted −0.288 < 0.001 0.82 (0.63–1.06) 0.126
  Model 1 −0.305 0.001 0.63 (0.42–0.93) 0.022
  Model 2 −0.298 0.001 0.64 (0.43–0.95) 0.027
 Girls
  Unadjusted −0.034 0.704 0.70 (0.49–1.00) 0.051
  Model 1 0.051 0.581 0.96 (0.60–1.54) 0.859
  Model 2 0.077 0.430 1.00 (0.61–1.64) 0.994
  1. HOMA-IR homeostatic model assessment of insulin resistance, QUICKI quantitative insulin sensitivity check index
  2. *Multiple ordinal regression was used with carotid intima media thickness as response with three ordered categories
  3. Adjusted for body fat mass percent, waist circumference, and physical activity
  4. Additionally adjusted for Tanner stages