Table 3 Genotype frequencies among controls and CTD cases
Genotype | Controls (n = 234) | CTD (N = 193) | p-Value | |
|---|---|---|---|---|
No. (%) | No. (%) | OR (95% CI) | ||
MTHFR C677T | ||||
CC | 83(35.47) | 65(33.68) | 1.00 | |
CT | 120(51.28) | 68(35.23) | 0.72(0.47–1.11) | 0.1493 |
TT | 31(13.25) | 60(31.09) | 2.47(1.42–4.32) | 0.0009* |
CT + TT | 151(64.53) | 128(66.32) | 1.08(0.73–1.62) | 0.6987 |
MTHFR A1298C | ||||
AA | 110(47.01) | 57(29.53) | 1.00 | |
AC | 67(28.63) | 71(36.79) | 2.05(1.28–3.21) | 0.0023* |
CC | 57(24.36) | 65(33.68) | 2.20(1.38–3.58) | 0.0011* |
AC + CC | 124(52.99) | 136(70.47) | 2.12(1.40–3.19) | 0.0002* |
SLC19A1 G80A | ||||
GG | 102(43.59) | 68(35.23) | 1.00 | |
AG | 82(35.04) | 69(35.75) | 1.26(0.82–1.96) | 0.3031 |
AA | 50(21.37) | 56(29.02) | 1.68(1.02–2.70) | 0.0371* |
AG + AA | 132(56.41) | 125(64.77) | 1.42(0.96–2.09) | 0.0791 |
MTR A2756G | ||||
AA | 87(37.18) | 66(34.20) | 1.00 | |
AG | 120(51.28) | 107(55.44) | 1.18(0.77–1.76) | 0.4426 |
GG | 27(11.54) | 20(10.36) | 0.98(0.51–1.92) | 0.9436 |
AG + GG | 147(62.82) | 127(65.80) | 1.14(0.77–1.70) | 0.5224 |
MTRR A66G | ||||
AA | 75(32.05) | 71(36.79) | 1.00 | |
AG | 116(49.57) | 92(47.67) | 0.84(0.55–1.28) | 0.4136 |
GG | 43(18.38) | 30(15.54) | 0.74(0.42–1.32) | 0.2917 |
AG + GG | 159(67.95) | 122(63.21) | 0.81(0.54–1.21) | 0.3045 |