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Table 3 Genotype frequencies among controls and CTD cases

From: Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population

Genotype Controls (n = 234) CTD (N = 193) p-Value
No. (%) No. (%) OR (95% CI)
MTHFR C677T
 CC 83(35.47) 65(33.68) 1.00  
 CT 120(51.28) 68(35.23) 0.72(0.47–1.11) 0.1493
 TT 31(13.25) 60(31.09) 2.47(1.42–4.32) 0.0009*
 CT + TT 151(64.53) 128(66.32) 1.08(0.73–1.62) 0.6987
MTHFR A1298C
 AA 110(47.01) 57(29.53) 1.00  
 AC 67(28.63) 71(36.79) 2.05(1.28–3.21) 0.0023*
 CC 57(24.36) 65(33.68) 2.20(1.38–3.58) 0.0011*
 AC + CC 124(52.99) 136(70.47) 2.12(1.40–3.19) 0.0002*
SLC19A1 G80A
 GG 102(43.59) 68(35.23) 1.00  
 AG 82(35.04) 69(35.75) 1.26(0.82–1.96) 0.3031
 AA 50(21.37) 56(29.02) 1.68(1.02–2.70) 0.0371*
 AG + AA 132(56.41) 125(64.77) 1.42(0.96–2.09) 0.0791
MTR A2756G
 AA 87(37.18) 66(34.20) 1.00  
 AG 120(51.28) 107(55.44) 1.18(0.77–1.76) 0.4426
 GG 27(11.54) 20(10.36) 0.98(0.51–1.92) 0.9436
 AG + GG 147(62.82) 127(65.80) 1.14(0.77–1.70) 0.5224
MTRR A66G
 AA 75(32.05) 71(36.79) 1.00  
 AG 116(49.57) 92(47.67) 0.84(0.55–1.28) 0.4136
 GG 43(18.38) 30(15.54) 0.74(0.42–1.32) 0.2917
 AG + GG 159(67.95) 122(63.21) 0.81(0.54–1.21) 0.3045
  1. OR odds ratio, CI confidence interval
  2. *means p-value< 0.05